HLA-B57

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major histocompatibility complex (human), class I, B57
Alleles B*5701, B*5702, B*5703, B*5704
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5701
B*5702
B*5703
B*5704
Locus chr.6 6p21.31

HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype B58.[1] The serotype identifies the more common HLA-B*58 gene products.[2] (For terminology help see: HLA-serotype tutorial)

[edit] Serotype

B57 and B17 serotype recognition of some more common HLA B*57 alleles[3]
B*57 B57 B17 Sample
allele  %  % size (N)
5701 92 5 3670
5702 78 8 65
5703 85 6 412
5704 67 7 32


[edit] Allele distribution

HLA B*5701 frequencies
freq
ref. Population (%)
[4] South Africa Natal Tamil 10.2
[4] India Tamil Nadu Nadar 8.2
[4] Spain Eastern Andalusia Gipsy 7.1
[4] Ireland South 5.8
[4] India North Delhi 4.9
[4] India New Delhi 3.8
[4] Ireland Northern 3.8
[4] Azores Central Islands 3.6
[4] Cuban White 3.6
[4] France South East 3.5
[4] China Guangzhou Han 3.3
[4] China North Han 3.3
[4] Czech Republic 3.3
[4] Russia Tuva (2) 3.3
[4] Cape Verde Northwestern Islands 3.2
[4] Azores Terceira Island 3.1
[4] Portugal South 3.1
[4] Thailand (3) 3.1
[4] Uganda Kampala 3.1
[4] Portugal Centre 3.0
[4] Tunisia 3.0
[4] India Andhra Pradesh Golla 2.9
[4] Belgium 2.0
[4] China Inner Mongolia 2.0
[4] Croatia 2.0
[4] Singapore Javanese Indonesians 2.0
[4] Singapore Riau Malay 2.0
[4] India North Hindus 1.9
[4] Bulgaria 1.8
[4] Thailand 1.8
[4] Finland 1.7
[4] Macedonia pop 4 1.6
[4] Madeira 1.6
[4] Australian Aborigine Cape York Peninsula 1.5
[4] Israel Arab Druse 1.5
[4] Sudanese 1.5
[4] Morocco Nador Metalsa (Berber) 1.4
[4] Azores Santa Maria and Sao Miguel 1.3
[4] Oman 1.3
[4] Mexico Mestizos 1.2
[4] Zambia Lusaka 1.1
[4] China Beijing Shijiazhuang Tianjian Han 1.0
[4] Iran Baloch 1.0
[4] USA Asian 1.0
B*5702
[4] Zambia Lusaka 2.3
[4] Senegal Niokholo Mandenka 1.6
[4] Kenya 1.4
[4] Mali Bandiagara 1.1
[4] South Africian Natal Zulu 1.0
B*5703
[4] Zambia Lusaka 5.7
[4] Cameroon Bakola Pygmy 5.0
[4] Ivory Coast Akan Adiopodoume 4.6
[4] Zimbabwe Harare Shona 4.4
[4] South Africian Natal Zulu 4.0
[4] Cameroon Bamileke 3.2
[4] Cameroon Beti 3.2
[4] Kenya Nandi 2.9
[4] Israel Ashkenazi and Non Ashkenazi Jews 2.8
[4] Cameroon Yaounde 2.7
[4] Tunisia Tunis 2.3
[4] Saudi Arabia Guraiat and Hail 1.5

[edit] References

  1. ^ Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem. 260 (22): 11924–33. PMID 2995352. 
  2. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660. 
v • d • e
HLA-B serotypes and allele groups

HLA-B · B5 (B51 · B52) · B7 · B8 · B12 (B44 · B45) · B13 · B14 (B64 · B65) · B15 (B62 · B63 · B70 · B71 · B75 · B76 · B77) · B16 (B38 · B39) · B17 (B57 · B58) · B18 · B21 (B49 · B50) · B22 (B54 · B55 · B56) · B27 · B35 · B37 · B40 (B60 · B61) · B41 · B42 · B46 · B47 · B48 · B53 · B59 · B67 · B73 · B78 · B81 · B*82 · B*83