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HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. ((For terminology help see: HLA-serotype tutorial)
[edit] Serotype
B53 and B35 serotype recognition of Some HLA B*35 allele-group gene products[3]
B*53 |
B53 |
B35 |
Sample |
allele |
% |
% |
size (N) |
5301 |
86 |
5 |
3054 |
5302 |
80 |
20 |
5 |
[edit] B*5301 allele frequencies
[edit] Haplotype frequencies
A*3601 : Cw*0401 : B*5301
|
|
freq |
ref. |
Population |
(%) |
|
Zimbabwe |
3.6 |
[4] |
Zambia Lusaka |
2.3 |
|
N. Afr. Negroid |
2.1 |
[4] |
Kenya Luo |
1.9 |
[4] |
Cameroon Yaounde |
1.7 |
[5] |
African American |
1.5 |
[4] |
Kenya Nandi |
1.3 |
[5] |
American Hispanic |
0.2 |
' |
A*6802 : Cw*0401 : B*5301 |
[4] |
Mali Bandihagara |
2.7 |
[5] |
African American |
1.4 |
[4] |
Kenya Nandi |
1.0 |
[5] |
Hispanic American |
0.6 |
[5] |
Caucasian American |
0.2 |
Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in african americans.
[edit] References
- ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ^ Allsopp CE, Hill AV, Kwiatkowski D, et al (1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol. 30 (2): 105–9. PMID 2022493.
- ^ derived from IMGT/HLA
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. PMID 12753660.
- ^ a b c d e Maiers M, Gragert L, Klitz W (2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.