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HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)
[edit] Serotype
B50 and B21 serotype recognition of some more common HLA B*50 alleles[3]
| B*50 |
B50 |
B21 |
Sample |
| allele |
% |
% |
size (N) |
| 5001 |
85 |
3 |
1700 |
The B*5002 by serotype definition is a B45 serotype.[4]
[edit] Allele distribution
HLA B*5001 frequencies
|
|
freq |
| ref. |
Population |
(%) |
| [5] |
Saudi Arabia Guraiat and Hail |
17.3 |
| [5] |
Tunisia |
10.0 |
| [5] |
Israel Arab Druse |
8.5 |
| [5] |
Morocco Nador Metalsa (Berber) |
7.3 |
| [5] |
Tunisia Tunis |
6.3 |
| [5] |
Israel Ashkenazi and Non Ashkenazi Jews |
5.5 |
| [5] |
Azores Terceira Island |
5.1 |
| [5] |
Georgia Svaneti Svans |
3.8 |
| [5] |
India North Delhi |
3.8 |
| [5] |
Italy Bergamo |
3.6 |
| [5] |
Georgia Tibilisi Kurds |
3.4 |
| [5] |
Italy North (1) |
3.3 |
| [5] |
Brazil Belo Horizonte |
3.2 |
| [5] |
Madeira |
3.2 |
| [5] |
Italy North Pavia |
3.1 |
| [5] |
Portugal South |
3.1 |
| [5] |
Oman |
3.0 |
| [5] |
Georgia Tibilisi Georgians |
2.8 |
| [5] |
Bulgaria |
2.7 |
| [5] |
Azores Santa Maria and Sao Miguel |
2.6 |
| [5] |
Spain Eastern Andalusia Gipsy |
2.5 |
| [5] |
Sudanese |
2.5 |
| [5] |
Czech Republic |
2.4 |
| [5] |
Spain Eastern Andalusia |
2.4 |
| [5] |
Spain Majorca and Minorca |
2.2 |
| [5] |
Burkina Faso Fulani |
2.0 |
| [5] |
China Inner Mongolia |
2.0 |
| [5] |
China North Han |
1.9 |
| [5] |
India North Hindus |
1.9 |
| [5] |
China Qinghai Hui |
1.8 |
| [5] |
Jordan Amman |
1.7 |
| [5] |
Russia Tuva (2) |
1.7 |
| [5] |
Spain Catalonia Girona |
1.7 |
| [5] |
Senegal Niokholo Mandenka |
1.6 |
| [5] |
Guinea Bissau |
1.5 |
| [5] |
India New Delhi |
1.5 |
| [5] |
Croatia |
1.3 |
| [5] |
Cuban Mulatto |
1.2 |
| [5] |
France South East |
1.2 |
| [5] |
Burkina Faso Rimaibe |
1.1 |
| [5] |
Mali Bandiagara |
1.1 |
| [5] |
Belgium |
1.0 |
| [5] |
Ireland Northern |
1.0 |
| [5] |
Ireland South |
1.0 |
| [5] |
Italy Sardinia pop3 |
1.0 |
| [5] |
South Africa Natal Tamil |
1.0 |
|
B*5002 |
| [5] |
Morocco Nador Metalsa (Berber) |
4.3 |
| [5] |
Portugal North |
1.1 |
| [5] |
Portugal South |
1.0 |
| [5] |
Madeira |
0.8 |
| [5] |
Tunisia Tunis |
0.6 |
[edit] References
- ^ Hildebrand WH, Madrigal JA, Belich MP, et al (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
- ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ^ derived from IMGT/HLA
- ^ Balas A, Santos S, García-Sánchez F, Lillo R, Merino L, Vicario JL (1998). "Characterization and distribution of HLA-B*5002 in a Spanish population sample". Tissue Antigens 52 (2): 183–6. PMID 9756408.
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
