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HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)
[edit] Serotype
B49 and B21 serotype recognition of some more common HLA B*49 alleles[3]
| B*49 |
B49 |
B21 |
Sample |
| allele |
% |
% |
size (N) |
| 4901 |
94 |
1 |
3002 |
[edit] Allele distribution
HLA B*4901 frequencies
|
|
freq |
| ref. |
Population |
(%) |
| [4] |
Portugal North |
8.7 |
| [4] |
Spain Basque Gipuzkoa Province |
6.1 |
| [4] |
Madeira |
5.9 |
| [4] |
Cameroon Yaounde |
5.4 |
| [4] |
Morocco Nador Metalsa (Berber) |
5.1 |
| [4] |
Kenya Nandi |
4.6 |
| [4] |
Sudanese |
4.3 |
| [4] |
Portugal South |
4.1 |
| [4] |
Tunisia Tunis |
4.0 |
| [4] |
India Jalpaiguri Toto |
3.8 |
| [4] |
Senegal Niokholo Mandenka |
3.7 |
| [4] |
Uganda Kampala |
3.7 |
| [4] |
Spain Eastern Andalusia |
3.5 |
| [4] |
Tunisia |
3.5 |
| [4] |
Georgia Tibilisi Kurds |
3.4 |
| [4] |
Spain Catalonia Girona |
3.4 |
| [4] |
Italy North (1) |
3.3 |
| [4] |
Cameroon Beti |
3.2 |
| [4] |
Israel Ashkenazi and Non Ashkenazi Jews |
3.2 |
| [4] |
Guinea Bissau |
3.1 |
| [4] |
France South East |
2.7 |
| [4] |
Israel Arab Druse |
2.5 |
| [4] |
Mali Bandiagara |
2.5 |
| [4] |
Jordan Amman |
2.4 |
| [4] |
Tunisia Ghannouch |
2.4 |
| [4] |
Georgia Tibilisi Georgians |
2.3 |
| [4] |
Saudi Arabia Guraiat and Hail |
2.2 |
| [4] |
Cameroon Bamileke |
1.9 |
| [4] |
Czech Republic |
1.9 |
| [4] |
Georgia Svaneti Svans |
1.9 |
| [4] |
Macedonia (4) |
1.9 |
| [4] |
Bulgaria |
1.8 |
| [4] |
Romanian |
1.6 |
| [4] |
Italy Bergamo |
1.1 |
| [4] |
Zambia Lusaka |
1.1 |
| [4] |
Belgium |
1.0 |
| [4] |
China North Han |
1.0 |
| [4] |
India Andhra Pradesh Golla |
1.0 |
| [4] |
Ireland Northern |
1.0 |
| [4] |
South Africian Natal Zulu |
1.0 |
[edit] References
- ^ Hildebrand WH, Madrigal JA, Belich MP, et al (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
- ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ^ derived from IMGT/HLA
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. PMID 12753660.
