HLA-B18

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major histocompatibility complex (human), class I, B18
Alleles B*1801
Alleles B*1802
Alleles B*1803
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*1801
EBI-HLA B*1802
EBI-HLA B*1803
Locus chr.6 6p21.31

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.


[edit] Serotype

B18 serotype recognition of Some HLA B*18 allele-group gene products[2]
B*18 B18 Sample
allele  %  % size (N)
1801 96 1641
1802 90 31
1803 83 29

[edit] Allele frequencies

HLA B*1801 frequencies
freq
ref. Population (%)
[3] Italy North pop 1 16.7
[3] Croatia 11.3
[3] Georgia Svaneti Svans 11.3
[3] Romanian 11.3
[3] Portugal South 11.2
[3] Singapore Riau Malay 9.9
[3] Bulgaria 9.1
[3] Israel Arab Druse 8.5
[3] Azores Central Islands 8.0
[3] Portugal Centre 8.0
[3] Finland 7.8
[3] Azores Santa Maria and Sao Miguel 7.7
[3] Czech Republic 7.5
[3] India Jalpaiguri Toto 7.5
[3] Iran Baloch 7.1
[3] Philippines Ivatan 7.0
[3] Thailand 6.7
[3] Tunisia 6.7
[3] Portugal North 6.5
[3] Zimbabwe Harare Shona 6.4
[3] Madeira 6.2
[3] Mexico Mestizos 6.1
[3] Kenya 5.9
[3] Belgium 5.1
[3] Morocco Nador Metalsa Class I 5.1
[3] Singapore Javanese Indonesians 5.1
[3] Israel Ashkenazi and Non Ashkenazi Jews 5.0
[3] Uganda Kampala 5.0
[3] Kenya Nandi 4.8
[3] Oman 4.7
[3] Georgia Tibilisi Georgians 4.6
[3] Bulgaria Gipsy 4.5
[3] France South East 4.3
[3] Kenya Luo 4.3
[3] Ireland South 4.2
[3] Russia Arkhangelsk Pomors 4.0
[3] Azores Terceira Island 3.9
[3] Guinea Bissau 3.8
[3] India New Delhi 3.8
[3] Spain Eastern Andalusia Gipsy 3.5
[3] Australia New South Wales 3.4
[3] Georgia Tibilisi Kurds 3.4
[3] Zambia Lusaka 3.4
[3] Cameroon Yaounde 2.7
[3] Senegal Niokholo Mandenka 2.7
[3] Cameroon Beti 2.3
[3] Ivory Coast Akan Adiopodoume 2.3
[3] Sudanese 2.3
[3] Saudi Arabia Guraiat and Hail 2.2
[3] South Africian Natal Zulu 2.0
[3] Thailand 2.0
[3] India Mumbai Marathas 1.9
[3] New Caledonia 1.9
[3] Papua New Guinea Wanigela 1.5
[3] Cameroon Bamileke 1.3


[edit] References

  1. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. PMID 12753660. 
v • d • e
HLA-B serotypes and allele groups

HLA-B · B5 (B51 · B52) · B7 · B8 · B12 (B44 · B45) · B13 · B14 (B64 · B65) · B15 (B62 · B63 · B70 · B71 · B75 · B76 · B77) · B16 (B38 · B39) · B17 (B57 · B58) · B18 · B21 (B49 · B50) · B22 (B54 · B55 · B56) · B27 · B35 · B37 · B40 (B60 · B61) · B41 · B42 · B46 · B47 · B48 · B53 · B59 · B67 · B73 · B78 · B81 · B*82 · B*83