HLA-A80

From Wikipedia, the free encyclopedia

major histocompatibility complex (human), class I, A80
Alleles A*8001
Structure (See HLA-A)
Identifiers
8001
Symbol(s) HLA-A
EBI-HLA A*8001
Locus chr.6 6p21.31

HLA-A80 (A80) is the least common HLA-A group. The serotype identifies the more common HLA-A*8001 gene product. A80 is almost exclusively found in africa and recent immigrants groups from West Africa

[edit] Serotype

A80 and A10 serotype recognition of Some HLA A*3601 allele-group gene products[1]
A*80 A80 A10 Sample
allele  %  % size (N)
8001 36 10 505

HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype.

[edit] Distribution and References

HLA A*8001 frequencies
freq
ref. Population (%)
[2] Bamileke (Cameroon) 1.9
Botswana 1.8
[3] Fulani (Burkino Faso) 1.0
[2] Bete(Cameroon) 0.6
Bubi(Eq. Guinea) 0.5
  1. ^ derived from IMGT/HLA
  2. ^ a b Torimiro JN, Carr JK, Wolfe ND, et al (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198. 
  3. ^ Modiano D, Luoni G, Petrarca V, et al (2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue Antigens 57 (2): 128–37. PMID 11260507. 
v • d • e
HLA-A serotypes

HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80