HLA-A74

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major histocompatibility complex (human), class I, A74
Alleles	A*7401 A*7403
Structure (See HLA-A)
Identifiers	7401 7403
Symbol(s)	HLA-A
EBI-HLA	A*7401
EBI-HLA	A*7403
Shared data
Locus	chr.6 6p21.31

HLA-A74 (A74) is an HLA-A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.

Contents 1 Serotype 1.1 Disease associations 2 A*74 allele Frequencies 3 References

[edit] Serotype

A74, A19 serotype recognition of Some HLA A*74 allele-group gene products^[1]

A*74	A74	A19	Sample
allele	%	%	size (N)
7401	40	11	119
7401	17		29

[edit] Disease associations

A significant association has been found between A74 and nasal polyposis.^[2]

[edit] A*74 allele Frequencies

HLA A*7401 frequencies

		freq
ref.	Population	(%)
[3]	Kenya	9.7
[3]	Cameroon Beti	8.3
[3]	Guinea Bissau	7.7
[3]	Burkina Faso Mossi	6.6
[3]	Uganda Kampala	5.2
[3]	Cameroon Yaounde	5.0
[3]	Cameroon Bamileke	4.5
[3]	Cameroon Sawa	3.8
[3]	Mali Bandiagara	3.6
[3]	Iran Baloch	2.8
[3]	Zimbabwe Harare Shona	2.7
[3]	Senegal Niokholo Mandenka	2.2
[3]	Burkina Faso Rimaibe	2.1
[3]	Kenya Nandi	1.7
[3]	Morocco Nador Metalsa	1.4
[3]	Thailand Northeast	1.2
[3]	Thailand	1.1
[3]	Jordon Amman	0.7
[3]	Jordon Amman	0.5
[3]	China South	0.5

HLA A*7403 frequencies

		freq
ref.	Population	(%)
[3]	Kenya Luo	7.3
[3]	Iran Baloch	0.6
[3]	Kenya	0.3
[3]	Uganda Kampala	0.3

[edit] References

v • d • e HLA-A serotypes HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80