HLA-A66

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major histocompatibility complex (human), class I, A66
Alleles A*6601
A*6602
A*6603
Structure (See HLA-A)
Identifiers
6601 6602 6603
Symbol(s) HLA-A
EBI-HLA A*6601
EBI-HLA A*6602
EBI-HLA A*6603
Shared data
Locus chr.6 6p21.31

HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A66 is more common in Africa and SW Europe. A66 is uncommon.


[edit] Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products[2]
A*66 A66 A10 A26 Other Sample
allele  %  %  %  % size (N)
6601 20 10 61 3 799
6602 38 10 4 31 205
6603 32 7 7 18 28





[edit] A*6601 Frequencies

HLA A*6601 frequencies
freq
ref. Population (%)
[3] Cameroon Sawa 7.7
[3] Kenya Luo 6.8
[3] Cameroon Sawa 7.7
[3] Cameroon Bakola Pygmy 5.8
[3] Cameroon Baka Pygmy 5.0
[3] Kenya Nandi 5.0
[3] Zimbabwe Harare Shona 0.2
[3] Cameroon Baka Pygmy 5.0
[3] Cameroon Beti 4.6
[3] Cameroon Bamileke 4.5
[3] India West Bhils 4.0
[3] Zimbabwe Harere Shona 3.8
[3] Uganda Kampala 3.8
[3] India Mumbia Marathas 2.5
[3] Cape Verde Northwestern 2.5
[3] Czech republic 2.4
[3] Morocco Nador Metalsa 2.1
[3] Central Portugal 2.0
[3] India West Parsis 2.0
[3] South Africian Natal Zulu 2.0
[3] Kenya 1.7
[3] Tunisia Tunis 1.7
[3] Guinea Bissau 1.5
[3] Georgia Tibilisi 1.4
[3] Zambia Lusaka 1.2
[3] Italy Bergamo 1.1
[3] Pakistan Karachi Parsi 1.1
[3] Oman 0.8
[3] Sudanese 0.8
[3] Belgium 0.5
[3] Southeast France 0.4
[3] Mongolia Buriat 0.4
[3] Wales 0.2
HLA A*6602 frequencies
freq
ref. Population (%)
[3] South Africian Natal Zulu 1.5
[3] Cameroon Yaounde 1.1
[3] Cameroon Bamileke 0.6
[3] Senegal Niokholo Mandenka 0.5
[3] Kenya Nandi 0.4
[3] Zimbabwe Harare Shona 0.2
[3] Wales 0.03
HLA A*6603 frequencies
freq
ref. Population (%)
[3] Cameroon Pygmy Baka 10.0
[3] Cameroon Bakola Pygmy 9.0
[3] Cameroon Sawa 7.7
[3] CAR Mbenzele Pygmy 2.8
[3] Zimbabwe Harare Shona 0.2


[edit] References

  1. ^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72–80. PMID 8475492. 
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. PMID 12753660. 
v • d • e
HLA-A serotypes

HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80