HLA-A43

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major histocompatibility complex (human), class I, A43
Alleles A*4301
Structure (See HLA-A)
Symbol(s) HLA-A
EBI-HLA A*4301
Locus chr.6 6p21.31

HLA-A43 (A43) is an HLA-A serotype. The serotype identifies the more common HLA-A*43 gene products. A43 is a split antigen type of the A10 broad antigen type. A*4301 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A43 is more common in Africa. A*4301 is rare.

[edit] Serotype

A26 serotype recognition of Some HLA A*4301 allele gene products[2]
A*43 --- A26 Sample
allele  %  % size (N)
4301 35 9


[edit] A43 frequencies

HLA A*4301 frequencies
freq
ref. Population (%)
[3] South Africa Tswana 4.9
[3] South Africian Natal Zulu 3.0
[3] China Yunnan Han 1.2
[3] Zambia Lusaka 1.2
[3] Pakistan Karachi Parsi 0.6
[3] India North Delhi 0.5
[3] Zimbabwe Harare Shona 0.4
[3] Italy 0.01
[3] China Shanghai 0.002

[edit] References

  1. ^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492. 
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660. 
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HLA-A serotypes

HLA-A · A1 · A2 · A3 · A9 (A23 · A24) · A10 (A25 · A26 · A34 · A43 · A66) · A11 · A19 (A29 · A30 · A31 · A32 · A33 · A74) · A28 (A68 · A69) · A36 · A80