HLA-A2
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major histocompatibility complex (human), class I, A2
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Alleles | A*0201 A*0202 A*0203 A*0205 A*0206 A*0207 A*0211 |
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Structure (See HLA-A) | ||
Identifiers |
*0201 *0202 *0203 *0205 *0206 *0207 *0211
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Symbol(s) | HLA-A2 | |
EBI-HLA | A*0201 | |
EBI-HLA | A*0202 | |
EBI-HLA | A*0203 | |
EBI-HLA | A*0205 | |
EBI-HLA | A*0206 | |
EBI-HLA | A*0207 | |
EBI-HLA | A*0211 | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-A2 (A2) is an HLA-A serotype. The serotype identifies the gene products of many HLA-A*02 alleles, including HLA-A*0201, *0202, *0203, *0206, and *0207 gene products. A*02 is globally common, but A*0201 is at high frequencies in Northern Asia and North America. A2 is the most diverse serotye, showing diversity in Eastern Africa and Southwest Asia. While the frequency of A*0201 in Northern Asia is high, its diversity is limited to A*0201 the less common Asian variants A*0203, A*0206.
Contents |
[edit] Serotype
A*02 | A2 | Sample | |
allele | % | % | size (N) |
*0201 | 98 | 6315 | |
*0202 | 81 | 859 | |
*0203 | 64 | 472 | |
*0204 | 78 | 28 | |
*0205 | 81 | 462 | |
*0206 | 68 | 636 | |
*0207 | 80 | 135 | |
*0211 | 74 | 228 |
The serotyping for the most abundant A*02 alleles is good. For A*0203, A*0206, A*0207 serotyping is borderline useful. There is a separate serotyping for A203 and A210. There are over 125 alleles identified (mostly by sequence homology) as being A2, of those 8 are nulls, and a large majority have unknown serotypes.
[edit] Disease Associations
[edit] By serotype
A2 Associated with spontaneous abortion in A2+/A[other] phenotypic children[2]
[edit] By haplotype
A*02:Cw*16 is associated with increased higher viral load in HIV[3]
[edit] A2-B Haplotypes
A2-B7 (Node in Netherlands) A2-B5
- A2-B51
- A2-B52
A2-B8
A2-B13
A2-B14
- A2-B64
- A2-B65
A2-B15
- A2-B62
- A2-B63
- A2-B70,71,75,76
- A2-B46 (Node in Southern China, may be most abundant haplotype)
A2-B16
- A2-B44
- A2-B45
A2-B18
A2-B27
A2-B35
A2-B37 A2-B39 (Node in North American Amerinds)
A2-B40
- A2-B60
- A2-B61
[edit] A2-Cw5-B44
freq | Rank in | |||
ref. | Population | (%) | Pop. | |
[4] | Cornish | 11.4 | 1 | 1 |
[5] | Ireland | 9.2 | 2 | |
[6] | Northern Ireland | 8.0 | 1 | 2 |
[4] | Sweden | 7.2 | 2 | |
[7] | Swiss | 6.9 | 2 | |
[4] | Polish | 6.2 | 1 | |
[4] | Spanish | 5.9 | 1 | |
[4] | Ukraine | 5.9 | 1 | |
[8] | Dutch Netherlands | 5.9 | 3 | |
[4] | Dane | 4.8 | 1 | |
[4] | Czech | 4.7 | 3 | |
[4] | Basque | 4.7 | 3 | |
[4] | Greek | 4.5 | 3 | |
[4] | Yugoslavian | 4.4 | ||
[4] | Hungarian | 3.5 | ||
[4] | British | 2.6 | 4 | |
[1] | Romania | 2.5 | ||
[4] | Austria | 2.4 | ||
1Cw*0501 (Eur.) |
A2-Cw5-B44 is the multi-serotype designation for the haplotype HLA-A*0201:C*0501:B*4402, the class I portion, of an ancetral haplotype (A2-B44-DR4-DQ8). The full haplotype is (for relative distances see Human leukocyte antigens:
A*0201 : C*0501 : B*4402 : DRB1*0401 : DQA1*0301 : DQB1*0302
Another haplotype that is more common in Central Europe is the (A2-B44-DR7-DQ2)
A*0201 : C*0501 : B*4402 : DRB1*0701 : DQA1*0201 : DQB1*0202
Over northwestern Europe A2-B44 shows a single common ancestor which contributed the Cw5 allele to the haplotype. The haplotype appears to have been introduced early in European prehistoric period, frequencies of the haplotype generally correlate with A1-Cw7-B8 and A2-B7. The haplotype is considerably more equilibrated relative to A1-B8 and a possible reason is gene flow from iberia or the east with related haplotypes after initial migrations.
[edit] References
- ^ derived from IMGT/HLA
- ^ Komlos L, Klein T, Korostishevsky M (2007). "HLA-A2 class I antigens in couples with recurrent spontaneous abortions". Int. J. Immunogenet. 34 (4): 241–6. doi: . PMID 17627758.
- ^ Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). "Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.". J Virol 76 (16): 8276–84. doi: . PMID 12134033.
- ^ a b c d e f g h i j k l m Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-262390-7.
- ^ Finch T, Lawlor E, Borton M, Barnes C, McNamara S, O'Riordan J, McCann S, Darke C (1997). "Distribution of HLA-A, B and DR genes and haplotypes in the Irish population.". Exp Clin Immunogenet 14 (4): 250–63. PMID 9523161.
- ^ Middleton D, Williams F, Hamill M, Meenagh A (2000). "Frequency of HLA-B alleles in a Caucasoid population determined by a two-stage PCR-SSOP typing strategy.". Hum Immunol 61 (12): 1285–97. doi: . PMID 11163085.
- ^ Grundschober C, Sanchez-Mazas A, Excoffier L, Langaney A, Jeannet M, Tiercy J (1994). "HLA-DPB1 DNA polymorphism in the Swiss population: linkage disequilibrium with other HLA loci and population genetic affinities.". Eur J Immunogenet 21 (3): 143–57. doi: . PMID 9098428.
- ^ Schipper R, Schreuder G, D'Amaro J, Oudshoorn M (1996). "HLA gene and haplotype frequencies in Dutch blood donors.". Tissue Antigens 48 (5): 562–74. PMID 8988539.
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