HLA-A26
From Wikipedia, the free encyclopedia
major histocompatibility complex (human), class I, A26
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Alleles | A*2601 A*2602 A*2603 A*2605 |
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Structure (See HLA-A) | ||
Identifiers |
2601 2602 2603 2605
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Symbol(s) | HLA-A | |
EBI-HLA | A*2601 | |
EBI-HLA | A*2602 | |
EBI-HLA | A*2603 | |
EBI-HLA | A*2605 | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-A26 (A26) is an HLA-A serotype. The serotype identifies the more common HLA-A*26 gene products. A26 is a split antigen of the A10 broad antigen serotype group. A*2601 is believed to be the ancestral type for the A10 group, this group also includes A25, A34, A43 and A66.[1] A26 is broadly distributed but A26 is unusually common in Japan with a number of variants.
[edit] Serotype
A*26 | A26 | A10 | Sample |
allele | % | % | size (N) |
2601 | 97 | 2 | 1730 |
2602 | 81 | 31 | |
2603 | 68 | 8 | 38 |
2605 | 90 | 10 |
Serotype recognition of most alleles is generally good.
[edit] Disease associations
A26 Serotype is associated with adult T-cell leukemia in Japanese.[2][3]
[edit] References
- ^ derived from IMGT/HLA
- ^ Nomura K, Utsunomiya A, Furushou H, Tara M, Hazeki M, Tokunaga M, Uozumi K, Hanada S, Yashiki S, Tajima K, Sonoda S (2006). "A family predisposition to adult T-cell leukemia.". J Clin Exp Hematop 46 (2): 67–71. PMID 17142956.
- ^ Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K, Sonoda S (2001). "HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes.". AIDS Res Hum Retroviruses 17 (11): 1047–61. doi: . PMID 11485622.
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