HLA-A11
From Wikipedia, the free encyclopedia
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major histocompatibility complex (human), class I, A11
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| Alleles | A*1101 A*1102 A*1103 A*1104 |
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| Structure (See HLA-A) | ||
| Identifiers |
*1101 *1102 *1103 *1104
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| Symbol(s) | HLA-A | |
| EBI-HLA | A*1101 | |
| EBI-HLA | A*1102 | |
| EBI-HLA | A*1103 | |
| EBI-HLA | A*1104 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A11 (A11) is an HLA-A serotype. The serotype identifies the more common HLA-A*11 gene products. A11 is more common in eastern Asia particularly along the coastal regions of china.
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[edit] Serotype
| A*11 | A11 | A10 | Sample |
| allele | % | % | size (N) |
| *1101 | 99 | 2530 | |
| *1102 | 76 | 42 | |
| *1103 | 83 | 18 | |
| *1104 | 60 | 6 | |
| *1105 | 66 | 33 | 3 |
Serotyping of A11 demonstrates better recognition of the *1101 gene products and poorer recognition of other A*11 gene products. Ther are ~40 recognized alleles of A*11. There is only one null classified as A11.
[edit] Disease Associations
[edit] By allele
A*1104 is associated with increased risk for cervical neoplasia resulting from human papillomavirus infection[2]
[edit] A11-B Haplotypes
A11-B13
- A11-Cw2-B13 (Li)
- A11-Cw9-B13 (Southern China & SE Asia)
- A11-C10-B13 Buyi
- A11-CBL-B13 Northern China
[edit] References
- ^ derived from IMGT/HLA
- ^ Chan D, Cheung T, Tam A, Cheung J, Yim S, Lo K, Siu N, Zhou D, Chan P (2005). "Risk association between human leukocyte antigen-A allele and high-risk human papillomavirus infection for cervical neoplasia in Chinese women.". J Infect Dis 192 (10): 1749–56. doi:. PMID 16235173.
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