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HLA-A10 is a broad antigen HLA-A serotype. The ancestral A10 type is believed to be A*2601, which via gene conversion with other HLA-A alleles produced A*2501, A*3401, A*4301 and A*6601.[1] A10 serotypes in general show a pattern of more recent expansion. A34 is an excellent example, appearing to have expanded from the middle east, with linkage disequilibrium with B alleles into Austronesia[2], South Pacific[3], Philippines[4] and as far north as Taiwan (where it is found in the Taiwan Ami and Yami tribal groups but rare in ethnic Chinese nor in Hong Kong Chinese). A*66 appears to have expanded from North Africa into the Middle East or Europe and A26 appears to have expanded Black Sea and, after the initial settlement from the southern West Pacific Rim peoples, into Japan . Whether this is a secondary migration from Africa or a re-expansion from within Eurasia is unclear.
[edit] References
- ^ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72–80. PMID 8475492.
- ^ Bugawan TL, Mack SJ, Stoneking M, Saha M, Beck HP, Erlich HA (1999). "HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus". Tissue Antigens 53 (4 Pt 1): 311–9. PMID 10323335.
- ^ Maitland K, Bunce M, Harding RM, et al (2004). "HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia". Tissue Antigens 64 (6): 678–86. doi:10.1111/j.1399-0039.2004.00328.x. PMID 15546341.
- ^ Bugawan TL, Klitz W, Alejandrino M, et al (2002). "The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos". Tissue Antigens 59 (6): 452–69. PMID 12445315.
