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| HIV Rev response element |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
311.9 nucleotides |
| Avg identity: |
87% |
|
The Rev response element (RRE) is a region in the RNA molecule of the HIV env gene. Rev has a nuclear export signal and is essential for the export of the viral RNA out of the nuclous. snRNAs have a nuclear retention signal and prevent unspliced RNA from being exported out of the nuclous. Rev with it's nuclear export signal can overcome this nuclear retenion signal and thus allows for the export of the RNA even if it's introns weren't spliced out.
[edit] References
- Le, SY; Zhang K, Maizel JV Jr (2002). "RNA molecules with structure dependent functions are uniquely folded". Nucleic Acids Res 30: 3574–3582. doi:10.1093/nar/gkf473. PMID 12177299.
[edit] External links
