Talk:Histone

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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) Changed rating to "high" as this is high school/SAT biology content. - tameeria 21:51, 18 February 2007 (UTC)

[edit] Unclear Sentence

Under the heading 'classes', near the end of the paragraph, it says "During meiosis, through the combination of nucleosome interactions with other proteins, the chromosome is assembled." I can't make sense of this sentence... and don't think it's as clear as it could be. --Seans Potato Business 03:52, 22 April 2007 (UTC)

Hopefully it's better now. --chodges 19:03, 6 August 2007 (UTC)

[edit] Time to update?

the picture in this article should probably be updated. It doesn't match with the text, and is misleading. The H2A-H2B dimers act as endcaps to the (H3-H4)₂ tetramer... Also we're kind of missing the flexibility and disorder of the H1 histone. I know you can't put everything in a picture, but the model of a nucleosome core particle illustrated here could be a bit better. --74.230.134.53 21:22, 14 May 2007 (UTC)

In my opinion, this figure is not suitable for use. This image is unsuitable for inclusion into the Histone page for the following reasons:

• The DNA shown is not biologically inspired. There is neither major nor minor groove, and its scale in proportion to the histone proteins is much too small.
• The DNA is displayed as having a right-handed superhelical twist around the histone octamer, when the the crystal structure (Luger, et al, Nature 389: 251, 1997, PDB entry 1AOI) shows that the DNA's superhelical spiral around the nucleosome is instead left-handed.

These major inaccuracies are probably strong enough to warrant its removal from the page. Can we remove this image from the Histone article? --chodges 18:09, 25 July 2007 (UTC)

[edit] Another unclear sentence

"There are some variant forms in some of the major classes." What are classes, and what are variant forms, and how does this relate to the previous paragraph? -Pgan002 02:09, 15 June 2007 (UTC)