Histone deacetylase 5

From Wikipedia, the free encyclopedia

Identifiers

HDAC5; FLJ90614; HD5; NY-CO-9

External IDs

OMIM: 605315 MGI: 1333784 HomoloGene: 3995

Gene ontology
Molecular Function:	• transcription corepressor activity • histone deacetylase activity • transcription factor binding • specific transcriptional repressor activity • hydrolase activity
Cellular Component:	• histone deacetylase complex • nucleus • cytoplasm • nuclear body
Biological Process:	• regulation of progression through cell cycle • negative regulation of transcription from RNA polymerase II promoter • chromatin remodeling • chromatin silencing • transcription • inflammatory response • heart development • B cell differentiation • negative regulation of striated muscle development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001015053 (mRNA)
NP_001015053 (protein)

NM_001077696 (mRNA)
NP_001071164 (protein)

Location

Chr 17: 39.51 - 39.56 Mb

Chr 11: 102.01 - 102.05 Mb

Pubmed search

[1]

[2]

Histone deacetylase 5, also known as HDAC5, is a human gene.^[1]

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Histone deacetylase

[edit] References

^ ^a ^b Entrez Gene: HDAC5 histone deacetylase 5.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators.". Trends Genet. 19 (5): 286–93. PMID 12711221.
Scanlan MJ, Chen YT, Williamson B, et al. (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies.". Int. J. Cancer 76 (5): 652–8. PMID 9610721.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
Grozinger CM, Hassig CA, Schreiber SL (1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4868–73. PMID 10220385.
Huang EY, Zhang J, Miska EA, et al. (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.". Genes Dev. 14 (1): 45–54. PMID 10640275.
Lemercier C, Verdel A, Galloo B, et al. (2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.". J. Biol. Chem. 275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID 10748098.
Grozinger CM, Schreiber SL (2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMID 10869435.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression.". Genes Dev. 14 (14): 1810–23. PMID 10898795.
Mahlknecht U, Schnittger S, Ottmann OG, et al. (2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5).". Biochim. Biophys. Acta 1493 (3): 342–8. PMID 11018260.
Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor.". J. Biol. Chem. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.
McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.". Nature 408 (6808): 106–11. doi:10.1038/35040593. PMID 11081517.
McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMID 11114197.
Fischle W, Dequiedt F, Fillion M, et al. (2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
McKinsey TA, Zhang CL, Olson EN (2001). "Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.". Mol. Cell. Biol. 21 (18): 6312–21. PMID 11509672.
Ozawa Y, Towatari M, Tsuzuki S, et al. (2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2.". Blood 98 (7): 2116–23. PMID 11567998.
Potter GB, Beaudoin GM, DeRenzo CL, et al. (2001). "The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.". Genes Dev. 15 (20): 2687–701. doi:10.1101/gad.916701. PMID 11641275.
Fischle W, Dequiedt F, Hendzel MJ, et al. (2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.". Mol. Cell 9 (1): 45–57. PMID 11804585.
Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
Huang Y, Tan M, Gosink M, et al. (2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis.". Cancer Res. 62 (10): 2913–22. PMID 12019172.