Histidine-tRNA ligase

From Wikipedia, the free encyclopedia

In enzymology, a histidine-tRNA ligase (EC 6.1.1.21) is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + tRNAHis AMP + diphosphate + L-histidyl-tRNAHis

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase. This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1ADJ, 1ADY, 1H4V, 1HTT, 1KMM, 1KMN, 1QE0, 1WU7, and 1X59.

[edit] References

• IUBMB entry for 6.1.1.21
• BRENDA references for 6.1.1.21 (Recommended.)
• PubMed references for 6.1.1.21
• PubMed Central references for 6.1.1.21
• Google Scholar references for 6.1.1.21
• von Tigerstrom M, Tener GM (1967). "Histidyl transfer ribonucleic acid synthetase from bakers' yeast". Can. J. Biochem. 45: 1067–74. PMID 6035970. 

[edit] External links

The CAS registry number for this enzyme class is 9068-78-4.

• IUBMB entry for 6.1.1.21

• KEGG entry for 6.1.1.21

• BRENDA entry for 6.1.1.21

• NiceZyme view of 6.1.1.21

• EC2PDB: PDB structures for 6.1.1.21

• PRIAM entry for 6.1.1.21

• PUMA2 entry for 6.1.1.21

• IntEnz: Integrated Enzyme entry for 6.1.1.21

• MetaCyc entry for 6.1.1.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004821: histidine-tRNA ligase

• AMIGO entry for GO code 0004821: histidine-tRNA ligase