HIST2H4A

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Histone cluster 2, H4a
PDB rendering based on 1aoi.
Available structures: 1aoi, 1eqz, 1f66, 1hio, 1hq3, 1id3, 1kx3, 1kx4, 1kx5, 1m18, 1m19, 1m1a, 1p34, 1p3a, 1p3b, 1p3f, 1p3g, 1p3i, 1p3k, 1p3l, 1p3m, 1p3o, 1p3p, 1s32, 1tzy, 1u35, 1zbb, 1zla, 2aro, 2cv5, 2f8n, 2fj7, 2hio, 2hue, 2io5, 2nzd
Identifiers
Symbol(s) HIST2H4A; H4; FO108; H4/n; H4F2; H4FN; HIST2H4; H4/o
External IDs OMIM: 142750 MGI: 2448443 HomoloGene: 88593
Orthologs
Human Mouse
Entrez 8370 320332


Refseq XM_001124639 (mRNA)
XP_001124639 (protein)		 NM_175652 (mRNA)
NP_783583 (protein)
Pubmed search [1] [2]

Histone cluster 2, H4a, also known as HIST2H4A, is a human gene.[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.[1]

[edit] References

  1. ^ a b Entrez Gene: HIST2H4A histone cluster 2, H4a.

[edit] Further reading

  • Pauli U, Chrysogelos S, Stein G, et al. (1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene.". Science 236 (4806): 1308–11. PMID 3035717. 
  • Sierra F, Stein G, Stein J (1983). "Structure and in vitro transcription of a human H4 histone gene.". Nucleic Acids Res. 11 (20): 7069–86. PMID 6314274. 
  • Green L, Van Antwerpen R, Stein J, et al. (1984). "A major human histone gene cluster on the long arm of chromosome 1.". Science 226 (4676): 838–40. PMID 6494913. 
  • Pelicci G, Lanfrancone L, Salcini AE, et al. (1995). "Constitutive phosphorylation of Shc proteins in human tumors.". Oncogene 11 (5): 899–907. PMID 7675449. 
  • Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M (1996). "Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay.". Biochim. Biophys. Acta 1296 (2): 219–27. PMID 8814229. 
  • Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.". Genomics 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID 9325046. 
  • Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284–94. PMID 9439656. 
  • El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. PMID 9566873. 
  • Kimura A, Horikoshi M (1999). "Tip60 acetylates six lysines of a specific class in core histones in vitro.". Genes Cells 3 (12): 789–800. PMID 10096020. 
  • Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476. 
  • Seo SB, McNamara P, Heo S, et al. (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein.". Cell 104 (1): 119–30. PMID 11163245. 
  • Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298. 
  • Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066. 
  • Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487–98. PMID 12408966. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hovhannisyan H, Cho B, Mitra P, et al. (2003). "Maintenance of open chromatin and selective genomic occupancy at the cell cycle-regulated histone H4 promoter during differentiation of HL-60 promyelocytic leukemia cells.". Mol. Cell. Biol. 23 (4): 1460–9. PMID 12556504. 
  • Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMID 12628926. 
  • Pivot-Pajot C, Caron C, Govin J, et al. (2003). "Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein.". Mol. Cell. Biol. 23 (15): 5354–65. PMID 12861021. 
  • Coleman MA, Miller KA, Beernink PT, et al. (2004). "Identification of chromatin-related protein interactions using protein microarrays.". Proteomics 3 (11): 2101–7. doi:10.1002/pmic.200300593. PMID 14595808. 
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