HIST1H3B
From Wikipedia, the free encyclopedia
Histone cluster 1, H3b
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PDB rendering based on 1aoi. | |||||
Available structures: 1aoi, 1eqz, 1f66, 1hio, 1hq3, 1kx3, 1kx4, 1kx5, 1m18, 1m19, 1m1a, 1p34, 1p3a, 1p3b, 1p3f, 1p3g, 1p3i, 1p3k, 1p3l, 1p3m, 1p3o, 1p3p, 1s32, 1tzy, 1u35, 1zbb, 1zla, 2aro, 2cv5, 2f8n, 2fj7, 2hio, 2hue, 2io5, 2nzd | |||||
Identifiers | |||||
Symbol(s) | HIST1H3B; H3/l; H3FL | ||||
External IDs | OMIM: 602819 MGI: 2145541 HomoloGene: 86902 | ||||
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Orthologs | |||||
Human | Mouse | ||||
Entrez | 8358 | 97908
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Refseq | NM_003537 (mRNA) NP_003528 (protein) |
NM_145073 (mRNA) NP_659539 (protein) |
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Pubmed search | [1] | [2] |
Histone cluster 1, H3b, also known as HIST1H3B, is a human gene.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[1]
[edit] References
[edit] Further reading
- Albig W, Kardalinou E, Drabent B, et al. (1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes.". Genomics 10 (4): 940–8. PMID 1916825.
- Marashi F, Helms S, Shiels A, et al. (1986). "Enhancer-facilitated expression of prokaryotic and eukaryotic genes using human histone gene 5' regulatory sequences.". Biochem. Cell Biol. 64 (4): 277–89. PMID 3013246.
- Zhong R, Roeder RG, Heintz N (1984). "The primary structure and expression of four cloned human histone genes.". Nucleic Acids Res. 11 (21): 7409–25. PMID 6647026.
- Ohe Y, Iwai K (1982). "Human spleen histone H3. Isolation and amino acid sequence.". J. Biochem. 90 (4): 1205–11. PMID 7309716.
- Kardalinou E, Eick S, Albig W, Doenecke D (1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones.". J. Cell. Biochem. 52 (4): 375–83. doi: . PMID 8227173.
- Albig W, Meergans T, Doenecke D (1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes.". Gene 184 (2): 141–8. PMID 9031620.
- Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster.". Genomics 40 (2): 314–22. doi: . PMID 9119399.
- Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284–94. PMID 9439656.
- El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. PMID 9566873.
- Goto H, Tomono Y, Ajiro K, et al. (1999). "Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.". J. Biol. Chem. 274 (36): 25543–9. PMID 10464286.
- Hsu JY, Sun ZW, Li X, et al. (2000). "Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.". Cell 102 (3): 279–91. PMID 10975519.
- Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. doi: . PMID 11080476.
- Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.". Nature 410 (6824): 116–20. doi: . PMID 11242053.
- Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. doi: . PMID 11689053.
- Yang L, Xia L, Wu DY, et al. (2002). "Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.". Oncogene 21 (1): 148–52. doi: . PMID 11791185.
- Goto H, Yasui Y, Nigg EA, Inagaki M (2002). "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.". Genes Cells 7 (1): 11–7. PMID 11856369.
- Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487–98. PMID 12408966.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Preuss U, Landsberg G, Scheidtmann KH (2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.". Nucleic Acids Res. 31 (3): 878–85. PMID 12560483.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi: . PMID 14574404.