HIST1H1T

From Wikipedia, the free encyclopedia

Histone cluster 1, H1t

Identifiers

HIST1H1T; H1FT; H1t; MGC163222; dJ221C16.2

External IDs

OMIM: 142712 MGI: 1888530 HomoloGene: 3889

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleosome • nucleus • chromosome
Biological Process:	• nucleosome assembly • multicellular organismal development • spermatogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005323 (mRNA)
NP_005314 (protein)

NM_010377 (mRNA)
NP_034507 (protein)

Location

Chr 6: 26.22 - 26.22 Mb

Chr 13: 23.7 - 23.7 Mb

Pubmed search

[1]

[2]

Histone cluster 1, H1t, also known as HIST1H1T, is a human gene.^[1]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[1]

[edit] References

^ ^a ^b Entrez Gene: HIST1H1T histone cluster 1, H1t.

[edit] Further reading

Drabent B, Kardalinou E, Doenecke D (1991). "Structure and expression of the human gene encoding testicular H1 histone (H1t).". Gene 103 (2): 263-8. PMID 1889752.
Koppel DA, Wolfe SA, Fogelfeld LA, et al. (1994). "Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6.". J. Cell. Biochem. 54 (2): 219-30. doi:10.1002/jcb.240540210. PMID 8175896.
Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6.". Genomics 16 (3): 649-54. doi:10.1006/geno.1993.1243. PMID 8325638.
Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster.". Genomics 40 (2): 314-22. doi:10.1006/geno.1996.4592. PMID 9119399.
Malanga M, Atorino L, Tramontano F, et al. (1998). "Poly(ADP-ribose) binding properties of histone H1 variants.". Biochim. Biophys. Acta 1399 (2-3): 154-60. PMID 9765591.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis.". Mol. Hum. Reprod. 4 (10): 939-45. PMID 9809674.
Wellman SE, Song Y, Mamoon NM (1999). "Sequence preference of mouse H1(0) and H1t.". Biochemistry 38 (40): 13112-8. PMID 10529182.
Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487-98. PMID 12408966.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.