HIST1H1E

From Wikipedia, the free encyclopedia

Histone cluster 1, H1e

Identifiers

HIST1H1E; H1.4; H1F4; MGC116819; dJ221C16.5

External IDs

OMIM: 142220 MGI: 1931527 HomoloGene: 74547

Gene ontology
Molecular Function:	• DNA binding • protein binding
Cellular Component:	• nucleosome • nucleus • chromosome
Biological Process:	• nucleosome assembly • chromosome organization and biogenesis (sensu Eukaryota) • nucleosome positioning

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005321 (mRNA)
NP_005312 (protein)

XM_990664 (mRNA)
XP_995758 (protein)

Location

Chr 6: 26.26 - 26.27 Mb

Chr 13: 23.63 - 23.63 Mb

Pubmed search

[1]

[2]

Histone cluster 1, H1e, also known as HIST1H1E, is a human gene.^[1]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[1]

[edit] References

^ ^a ^b Entrez Gene: HIST1H1E histone cluster 1, H1e.

[edit] Further reading

Albig W, Kardalinou E, Drabent B, et al. (1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes.". Genomics 10 (4): 940–8. PMID 1916825.
Ohe Y, Hayashi H, Iwai K (1986). "Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b.". J. Biochem. 100 (2): 359–68. PMID 3782055.
Strom R, Santoro R, D'Erme M, et al. (1995). "Specific variants of H1 histone regulate CpG methylation in eukaryotic DNA.". Gene 157 (1-2): 253–6. PMID 7607502.
Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6.". Genomics 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster.". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284–94. PMID 9439656.
Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487–98. PMID 12408966.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Morrison H, Jeppesen P (2003). "Allele-specific underacetylation of histone H4 downstream from promoters is associated with X-inactivation in human cells.". Chromosome Res. 10 (7): 579–95. PMID 12498347.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID 15595731.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Daujat S, Zeissler U, Waldmann T, et al. (2006). "HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.". J. Biol. Chem. 280 (45): 38090–5. doi:10.1074/jbc.C500229200. PMID 16127177.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Trojer P, Li G, Sims RJ, et al. (2007). "L3MBTL1, a histone-methylation-dependent chromatin lock.". Cell 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172.