HIST1H1C

From Wikipedia, the free encyclopedia

Histone cluster 1, H1c

Identifiers

HIST1H1C; H1.2; H1F2; MGC3992

External IDs

OMIM: 142710 MGI: 1931526 HomoloGene: 68455

Gene ontology
Molecular Function:	• DNA binding • protein binding
Cellular Component:	• nucleosome • nucleus • chromosome
Biological Process:	• nucleosome assembly • chromosome organization and biogenesis (sensu Eukaryota) • nucleosome positioning

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005319 (mRNA)
NP_005310 (protein)

NM_015786 (mRNA)
NP_056601 (protein)

Location

Chr 6: 26.16 - 26.16 Mb

Chr 13: 23.75 - 23.75 Mb

Pubmed search

[1]

[2]

Histone cluster 1, H1c, also known as HIST1H1C, is a human gene.^[1]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[1]

[edit] References

^ ^a ^b Entrez Gene: HIST1H1C histone cluster 1, H1c.

[edit] Further reading

Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.". J. Biochem. 106 (5): 844-57. PMID 2613692.
Eick S, Nicolai M, Mumberg D, Doenecke D (1989). "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes.". Eur. J. Cell Biol. 49 (1): 110-5. PMID 2759094.
Eilers A, Bouterfa H, Triebe S, Doenecke D (1994). "Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription.". Eur. J. Biochem. 223 (2): 567-74. PMID 8055927.
Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6.". Genomics 16 (3): 649-54. doi:10.1006/geno.1993.1243. PMID 8325638.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284-94. PMID 9439656.
Richardson RT, Batova IN, Widgren EE, et al. (2000). "Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein.". J. Biol. Chem. 275 (39): 30378-86. doi:10.1074/jbc.M003781200. PMID 10893414.
Parseghian MH, Newcomb RL, Winokur ST, Hamkalo BA (2001). "The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.". Chromosome Res. 8 (5): 405-24. PMID 10997781.
Marzluff WF, Gongidi P, Woods KR, et al. (2003). "The human and mouse replication-dependent histone genes.". Genomics 80 (5): 487-98. PMID 12408966.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.". J. Proteome Res. 3 (6): 1219-27. doi:10.1021/pr0498887. PMID 15595731.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Duce JA, Smith DP, Blake RE, et al. (2006). "Linker histone H1 binds to disease associated amyloid-like fibrils.". J. Mol. Biol. 361 (3): 493-505. doi:10.1016/j.jmb.2006.06.038. PMID 16854430.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.