HIRIP3

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HIRA interacting protein 3
Identifiers
Symbol(s) HIRIP3;
External IDs OMIM: 603365 MGI: 2142364 HomoloGene: 18218
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8479 233876
Ensembl ENSG00000149929 ENSMUSG00000042606
Uniprot Q9BW71 n/a
Refseq NM_003609 (mRNA)
NP_003600 (protein)		 NM_172746 (mRNA)
NP_766334 (protein)
Location Chr 16: 29.91 - 29.91 Mb Chr 7: 126.65 - 126.66 Mb
Pubmed search [1] [2]

HIRA interacting protein 3, also known as HIRIP3, is a human gene.[1]

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism.[1]

[edit] References

  1. ^ a b Entrez Gene: HIRIP3 HIRA interacting protein 3.

[edit] Further reading

  • Assrir N, Filhol O, Galisson F, Lipinski M (2007). "HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2.". Biol. Chem. 388 (4): 391-8. doi:10.1515/BC.2007.045. PMID 17391060. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243. 
  • Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339-46. doi:10.1021/pr050048h. PMID 16083285. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lorain S, Quivy JP, Monier-Gavelle F, et al. (1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA.". Mol. Cell. Biol. 18 (9): 5546-56. PMID 9710638. 
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