HIPK3

From Wikipedia, the free encyclopedia

Homeodomain interacting protein kinase 3

Identifiers

HIPK3; DYRK6; FIST3; PKY; YAK1

External IDs

OMIM: 604424 MGI: 1314882 HomoloGene: 55923

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity • protein kinase binding
Cellular Component:	• nucleus • cytoplasm • PML body
Biological Process:	• transcription • regulation of transcription, DNA-dependent • apoptosis • anti-apoptosis • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • negative regulation of JNK activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001048200 (mRNA)
NP_001041665 (protein)

XM_001001388 (mRNA)
XP_001001388 (protein)

Location

Chr 11: 33.24 - 33.33 Mb

Chr 2: 104.23 - 104.3 Mb

Pubmed search

[1]

[2]

Homeodomain interacting protein kinase 3, also known as HIPK3, is a human gene.^[1]

[edit] References

^ Entrez Gene: HIPK3 homeodomain interacting protein kinase 3.

[edit] Further reading

Begley DA, Berkenpas MB, Sampson KE, Abraham I (1997). "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1.". Gene 200 (1-2): 35–43. PMID 9373137.
Moilanen AM, Karvonen U, Poukka H, et al. (1999). "Activation of androgen receptor function by a novel nuclear protein kinase.". Mol. Biol. Cell 9 (9): 2527–43. PMID 9725910.
Kim YH, Choi CY, Lee SJ, et al. (1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.". J. Biol. Chem. 273 (40): 25875–9. PMID 9748262.
Scaffidi C, Volkland J, Blomberg I, et al. (2000). "Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase.". J. Immunol. 164 (3): 1236–42. PMID 10640736.
Nupponen NN, Visakorpi T (2000). "Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization.". Cytogenet. Cell Genet. 87 (1-2): 102–3. PMID 10640824.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.
Rochat-Steiner V, Becker K, Micheau O, et al. (2000). "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.". J. Exp. Med. 192 (8): 1165–74. PMID 11034606.
Curtin JF, Cotter TG (2004). "JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.". J. Biol. Chem. 279 (17): 17090–100. doi:10.1074/jbc.M307629200. PMID 14766760.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon.". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
Lan HC, Li HJ, Lin G, et al. (2007). "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.". Mol. Cell. Biol. 27 (6): 2027–36. doi:10.1128/MCB.02253-06. PMID 17210646.