HIPK2

From Wikipedia, the free encyclopedia

Homeodomain interacting protein kinase 2

Identifiers

HIPK2; PRO0593

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • transcription corepressor activity • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity • virion binding
Cellular Component:	• nucleus • cytoplasm • nuclear body
Biological Process:	• regulation of progression through cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • protein amino acid phosphorylation • apoptosis • smoothened signaling pathway • positive regulation of cell proliferation • induction of apoptosis by intracellular signals • anterior/posterior pattern formation • virus-host interaction • positive regulation of transforming growth factor beta receptor signaling pathway • DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis • positive regulation of DNA binding • positive regulation of JNK cascade

Orthologs

Human

Mouse

Entrez

28996

n/a

Refseq

NM_022740 (mRNA)
NP_073577 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Homeodomain interacting protein kinase 2, also known as HIPK2, is a human gene.

HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: HIPK2 homeodomain interacting protein kinase 2.

[edit] Further reading

Möller A, Schmitz ML (2004). "Viruses as hijackers of PML nuclear bodies.". Arch. Immunol. Ther. Exp. (Warsz.) 51 (5): 295–300. PMID 14626429.
Calzado MA, Renner F, Roscic A, Schmitz ML (2007). "HIPK2: a versatile switchboard regulating the transcription machinery and cell death.". Cell Cycle 6 (2): 139–43. PMID 17245128.
Kim YH, Choi CY, Lee SJ, et al. (1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.". J. Biol. Chem. 273 (40): 25875–9. PMID 9748262.
Kim YH, Choi CY, Kim Y (1999). "Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12350–5. PMID 10535925.
Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.". J. Biol. Chem. 274 (47): 33194–7. PMID 10559189.
Li X, Wang Y, Debatin KM, Hug H (2000). "The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.". Biochem. Biophys. Res. Commun. 277 (2): 513–7. doi:10.1006/bbrc.2000.3700. PMID 11032752.
Hofmann TG, Mincheva A, Lichter P, et al. (2001). "Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.". Biochimie 82 (12): 1123–7. PMID 11120354.
Wang Y, Hofmann TG, Runkel L, et al. (2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2.". Biochim. Biophys. Acta 1518 (1-2): 168–72. PMID 11267674.
Missero C, Pirro MT, Simeone S, et al. (2001). "The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription.". J. Biol. Chem. 276 (36): 33569–75. doi:10.1074/jbc.M104963200. PMID 11438542.
Wang Y, Debatin KM, Hug H (2003). "HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels.". BMC Mol. Biol. 2: 8. PMID 11532197.
Pierantoni GM, Fedele M, Pentimalli F, et al. (2001). "High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.". Oncogene 20 (43): 6132–41. doi:10.1038/sj.onc.1204635. PMID 11593421.
Hofmann TG, Möller A, Sirma H, et al. (2002). "Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.". Nat. Cell Biol. 4 (1): 1–10. doi:10.1038/ncb715. PMID 11740489.
D'Orazi G, Cecchinelli B, Bruno T, et al. (2002). "Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.". Nat. Cell Biol. 4 (1): 11–9. doi:10.1038/ncb714. PMID 11780126.
Pierantoni GM, Bulfone A, Pentimalli F, et al. (2002). "The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.". Biochem. Biophys. Res. Commun. 290 (3): 942–7. doi:10.1006/bbrc.2001.6310. PMID 11798164.
Kim EJ, Park JS, Um SJ (2002). "Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.". J. Biol. Chem. 277 (35): 32020–8. doi:10.1074/jbc.M200153200. PMID 11925430.
Wang Y, Marion Schneider E, Li X, et al. (2002). "HIPK2 associates with RanBPM.". Biochem. Biophys. Res. Commun. 297 (1): 148–53. PMID 12220523.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Tomasini R, Samir AA, Carrier A, et al. (2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.". J. Biol. Chem. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. PMID 12851404.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Harada J, Kokura K, Kanei-Ishii C, et al. (2003). "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.". J. Biol. Chem. 278 (40): 38998–9005. doi:10.1074/jbc.M307112200. PMID 12874272.