HIPK1

From Wikipedia, the free encyclopedia

Homeodomain interacting protein kinase 1

Identifiers

HIPK1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2

External IDs

OMIM: 608003 MGI: 1314873 HomoloGene: 56483

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • kinase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_152696 (mRNA)
NP_689909 (protein)

NM_010432 (mRNA)
NP_034562 (protein)

Location

Chr 1: 114.27 - 114.32 Mb

Chr 3: 103.87 - 103.91 Mb

Pubmed search

[1]

[2]

Homeodomain interacting protein kinase 1, also known as HIPK1, is a human gene.^[1]

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: HIPK1 homeodomain interacting protein kinase 1.

[edit] Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Kim YH, Choi CY, Lee SJ, et al. (1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.". J. Biol. Chem. 273 (40): 25875–9. PMID 9748262.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ecsedy JA, Michaelson JS, Leder P (2003). "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.". Mol. Cell. Biol. 23 (3): 950–60. PMID 12529400.
Kondo S, Lu Y, Debbas M, et al. (2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5431–6. doi:10.1073/pnas.0530308100. PMID 12702766.
Song JJ, Lee YJ (2004). "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.". J. Biol. Chem. 278 (47): 47245–52. doi:10.1074/jbc.M213201200. PMID 12968034.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Li X, Zhang R, Luo D, et al. (2005). "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.". J. Biol. Chem. 280 (15): 15061–70. doi:10.1074/jbc.M414262200. PMID 15701637.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.