HIP2

From Wikipedia, the free encyclopedia

Huntingtin interacting protein 2

PDB rendering based on 1yla.

Available structures: 1yla, 2bep, 2bf8, 2o25

Identifiers

Symbol(s)

HIP2; HYPG; LIG; UBE2K

External IDs

OMIM: 602846 MGI: 1858216 HomoloGene: 3903

Gene ontology
Molecular Function:	• transcription factor activity • ubiquitin-protein ligase activity • ligase activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005339 (mRNA)
NP_005330 (protein)

NM_016786 (mRNA)
NP_058066 (protein)

Location

Chr 4: 39.38 - 39.46 Mb

Chr 5: 65.82 - 65.88 Mb

Pubmed search

[1]

[2]

Huntingtin interacting protein 2, also known as HIP2, is a human gene.^[1]

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.^[1]

[edit] References

^ ^a ^b Entrez Gene: HIP2 huntingtin interacting protein 2.

[edit] Further reading

Petersén A, Mani K, Brundin P (1999). "Recent advances on the pathogenesis of Huntington's disease.". Exp. Neurol. 157 (1): 1–18. doi:10.1006/exnr.1998.7006. PMID 10222105.
Kalchman MA, Graham RK, Xia G, et al. (1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.". J. Biol. Chem. 271 (32): 19385–94. PMID 8702625.
Coux O, Goldberg AL (1998). "Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.". J. Biol. Chem. 273 (15): 8820–8. PMID 9535861.
Whitby FG, Xia G, Pickart CM, Hill CP (1999). "Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.". J. Biol. Chem. 273 (52): 34983–91. PMID 9857030.
Kikuchi J, Furukawa Y, Kubo N, et al. (2000). "Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis.". Arterioscler. Thromb. Vasc. Biol. 20 (1): 128–34. PMID 10634809.
Furukawa Y, Kubo N, Kikuchi J, et al. (2000). "Regulation of macrophage-specific gene expression by degenerated lipoproteins.". Electrophoresis 21 (2): 338–46. doi:10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9. PMID 10675012.
Lee SJ, Choi JY, Sung YM, et al. (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme.". FEBS Lett. 503 (1): 61–4. PMID 11513855.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Flierman D, Coleman CS, Pickart CM, et al. (2006). "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11589–94. doi:10.1073/pnas.0605215103. PMID 16868077.
de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.". Mol. Cell. Neurosci. 34 (1): 10–9. doi:10.1016/j.mcn.2006.09.006. PMID 17092742.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Christensen DE, Brzovic PS, Klevit RE. "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.". Nat. Struct. Mol. Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885.