HIF-1 alpha IRES

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HIF-1 alpha IRES

Type:	Cis-reg; IRES;
2° structure:	Predicted; RNAFOLD; Moxon SJ
Seed alignment:	http://ifr31w3.toulouse.inserm.fr/IRESdatabase/
Avg length:	270.8 nucleotides
Avg identity:	84%

The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap-independent translation. The HIF-1α internal ribosome entry site (IRES) allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1]. The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia.

[edit] References

[1] Lang, KJ; Kappel A, Goodall GJ (2002). "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia". Mol Biol Cell 13: 1792–1801. doi:10.1091/mbc.02-02-0017. PMID 12006670.