HIBADH

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It has been suggested that this article or section be merged with 3-hydroxyisobutyrate dehydrogenase. (Discuss)

3-hydroxyisobutyrate dehydrogenase

PDB rendering based on 2gf2.

Available structures: 2gf2, 2i9p

Identifiers

Symbol(s)

HIBADH; MGC40361; NS5ATP1

External IDs

OMIM: 608475 MGI: 1889802 HomoloGene: 15088

Gene ontology
Molecular Function:	• phosphogluconate dehydrogenase (decarboxylating) activity • 3-hydroxyisobutyrate dehydrogenase activity • oxidoreductase activity • NAD binding
Cellular Component:	• mitochondrion
Biological Process:	• pentose-phosphate shunt • valine metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_152740 (mRNA)
NP_689953 (protein)

NM_145567 (mRNA)
NP_663542 (protein)

Location

Chr 7: 27.53 - 27.67 Mb

Chr 6: 52.48 - 52.57 Mb

Pubmed search

[1]

[2]

3-hydroxyisobutyrate dehydrogenase, also known as HIBADH, is a human gene.^[1]

3-hydroxyisobutyrate dehydrogenase (3-hydroxy-2-methylpropanoate:NAD(+) oxidoreductase, EC 1.1.1.31) is a dimeric mitochondrial enzyme that catalyzes the NAD(+)-dependent, reversible oxidation of 3-hydroxyisobutyrate, an intermediate of valine catabolism, to methylmalonate semialdehyde.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: HIBADH 3-hydroxyisobutyrate dehydrogenase.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993.". Electrophoresis 14 (11): 1216–22. PMID 8313870.
Rougraff PM, Paxton R, Kuntz MJ, et al. (1988). "Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver.". J. Biol. Chem. 263 (1): 327–31. PMID 3335502.
Rougraff PM, Zhang B, Kuntz MJ, et al. (1989). "Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases.". J. Biol. Chem. 264 (10): 5899–903. PMID 2647728.