HEXIM2

From Wikipedia, the free encyclopedia

Hexamthylene bis-acetamide inducible 2

Identifiers

HEXIM2; L3; FLJ32384

External IDs

MGI: 1918309 HomoloGene: 16946

Gene ontology
Molecular Function:	• cyclin-dependent protein kinase inhibitor activity • protein binding • transcription repressor activity • snRNA binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • negative regulation of cyclin-dependent protein kinase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_144608 (mRNA)
NP_653209 (protein)

XM_203501 (mRNA)
XP_203501 (protein)

Location

Chr 17: 40.59 - 40.6 Mb

Chr 11: 102.95 - 102.96 Mb

Pubmed search

[1]

[2]

Hexamthylene bis-acetamide inducible 2, also known as HEXIM2, is a human gene.^[1]

[edit] References

^ Entrez Gene: HEXIM2 hexamthylene bis-acetamide inducible 2.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Michels AA, Nguyen VT, Fraldi A, et al. (2003). "MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.". Mol. Cell. Biol. 23 (14): 4859–69. PMID 12832472.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.". Oncogene 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
Byers SA, Price JP, Cooper JJ, et al. (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
Li Q, Price JP, Byers SA, et al. (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
Fraldi A, Varrone F, Napolitano G, et al. (2006). "Inhibition of Tat activity by the HEXIM1 protein.". Retrovirology 2: 42. doi:10.1186/1742-4690-2-42. PMID 15992410.