HERC5

From Wikipedia, the free encyclopedia

Hect domain and RLD 5

Identifiers

HERC5; CEB1; CEBP1

External IDs

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • ligase activity
Cellular Component:	• intracellular
Biological Process:	• regulation of cyclin-dependent protein kinase activity • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_016323 (mRNA)
NP_057407 (protein)

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n/a (protein)

Location

Chr 4: 89.6 - 89.65 Mb

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Pubmed search

[1]

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Hect domain and RLD 5, also known as HERC5, is a human gene.^[1]

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.^[1]

[edit] References

^ ^a ^b Entrez Gene: HERC5 hect domain and RLD 5.

[edit] Further reading

Salon C, Merdzhanova G, Brambilla C, et al. (2007). "E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors.". Oncogene 26 (48): 6927-36. doi:10.1038/sj.onc.1210499. PMID 17471231.
Takeuchi T, Inoue S, Yokosawa H (2006). "Identification and Herc5-mediated ISGylation of novel target proteins.". Biochem. Biophys. Res. Commun. 348 (2): 473-7. doi:10.1016/j.bbrc.2006.07.076. PMID 16884686.
Wong JJ, Pung YF, Sze NS, Chin KC (2006). "HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.". Proc. Natl. Acad. Sci. U.S.A. 103 (28): 10735-40. doi:10.1073/pnas.0600397103. PMID 16815975.
Dastur A, Beaudenon S, Kelley M, et al. (2006). "Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.". J. Biol. Chem. 281 (7): 4334-8. doi:10.1074/jbc.M512830200. PMID 16407192.
Hochrainer K, Mayer H, Baranyi U, et al. (2005). "The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.". Genomics 85 (2): 153-64. doi:10.1016/j.ygeno.2004.10.006. PMID 15676274.
Kroismayr R, Baranyi U, Stehlik C, et al. (2005). "HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells.". J. Cell. Sci. 117 (Pt 20): 4749-56. doi:10.1242/jcs.01338. PMID 15331633.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089-94. doi:10.1073/pnas.241522398. PMID 11752456.
Mitsui K, Nakanishi M, Ohtsuka S, et al. (2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.". Biochem. Biophys. Res. Commun. 266 (1): 115-22. doi:10.1006/bbrc.1999.1777. PMID 10581175.