HERC2

From Wikipedia, the free encyclopedia

Hect domain and RLD 2

Identifiers

HERC2; D15F37S1; DKFZp547P028; KIAA0393; jdf2; p528

External IDs

OMIM: 605837 MGI: 103234 HomoloGene: 3430

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • guanyl-nucleotide exchange factor activity • zinc ion binding • heme binding
Cellular Component:	• cellular_component • intracellular
Biological Process:	• ubiquitin cycle • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004667 (mRNA)
NP_004658 (protein)

NM_010418 (mRNA)
NP_034548 (protein)

Location

Chr 15: 26.03 - 26.24 Mb

Chr 7: 55.92 - 56.1 Mb

Pubmed search

[1]

[2]

Hect domain and RLD 2, also known as HERC2, is a human gene.^[1]

[edit] References

^ Entrez Gene: HERC2 hect domain and RLD 2.

[edit] Further reading

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841.
Ji Y, Walkowicz MJ, Buiting K, et al. (1999). "The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.". Hum. Mol. Genet. 8 (3): 533-42. PMID 9949213.
Walkowicz M, Ji Y, Ren X, et al. (1999). "Molecular characterization of radiation- and chemically induced mutations associated with neuromuscular tremors, runting, juvenile lethality, and sperm defects in jdf2 mice.". Mamm. Genome 10 (9): 870-8. PMID 10441737.
Ji Y, Rebert NA, Joslin JM, et al. (2000). "Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human.". Genome Res. 10 (3): 319-29. PMID 10720573.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089-94. doi:10.1073/pnas.241522398. PMID 11752456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205-10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Sulem P, Gudbjartsson DF, Stacey SN, et al. (2007). "Genetic determinants of hair, eye and skin pigmentation in Europeans.". Nat. Genet. 39 (12): 1443-52. doi:10.1038/ng.2007.13. PMID 17952075.