HEMGN

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Hemogen
Identifiers
Symbol(s) HEMGN; EDAG; EDAG-1
External IDs OMIM: 610715 MGI: 2136910 HomoloGene: 14223
Orthologs
Human Mouse
Entrez 55363 93966
Ensembl ENSG00000136929 ENSMUSG00000028332
Uniprot Q9BXL5 Q9ERZ0
Refseq NM_018437 (mRNA)
NP_060907 (protein)		 NM_053149 (mRNA)
NP_444379 (protein)
Location Chr 9: 99.73 - 99.75 Mb Chr 4: 46.42 - 46.43 Mb
Pubmed search [1] [2]

Hemogen, also known as HEMGN, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: HEMGN hemogen.

[edit] Further reading

  • Yang LV, Nicholson RH, Kaplan J, et al. (2001). "Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms.". Mech. Dev. 104 (1-2): 105-11. PMID 11404085. 
  • Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.". Genome Res. 11 (8): 1392-403. doi:10.1101/gr.175501. PMID 11483580. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yang LV, Heng HH, Wan J, et al. (2004). "Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.". Dev. Dyn. 228 (4): 606-16. doi:10.1002/dvdy.10399. PMID 14648837. 
  • Liu CC, Chou YL, Ch'ang LY (2004). "Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells.". J. Biomed. Sci. 11 (1): 104-16. doi:10.1159/000075293. PMID 14730214. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053. 
  • Li CY, Zhan YQ, Xu CW, et al. (2005). "EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B.". Cell Death Differ. 11 (12): 1299-308. doi:10.1038/sj.cdd.4401490. PMID 15332117. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • An LL, Li G, Wu KF, et al. (2005). "High expression of EDAG and its significance in AML.". Leukemia 19 (8): 1499-502. doi:10.1038/sj.leu.2403808. PMID 15920494. 
  • Yang LV, Wan J, Ge Y, et al. (2006). "The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells.". Leukemia 20 (3): 417-25. doi:10.1038/sj.leu.2404105. PMID 16437149. 
  • Ling B, Zhou Y, Feng D, et al. (2007). "Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells.". Oncol. Rep. 18 (3): 659-64. PMID 17671716. 
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