HELLS

From Wikipedia, the free encyclopedia

Helicase, lymphoid-specific

Identifiers

HELLS; FLJ10339; LSH; Nbla10143; PASG; SMARCA6

External IDs

OMIM: 603946 MGI: 106209 HomoloGene: 50037

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • helicase activity • ATP binding • hydrolase activity
Cellular Component:	• nucleus • centric heterochromatin
Biological Process:	• methylation-dependent chromatin silencing • transcription • regulation of transcription, DNA-dependent • cell cycle • mitosis • multicellular organismal development • maintenance of DNA methylation • centric heterochromatin formation • lymphocyte proliferation • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018063 (mRNA)
NP_060533 (protein)

NM_008234 (mRNA)
NP_032260 (protein)

Location

Chr 10: 96.3 - 96.36 Mb

Chr 19: 39 - 39.03 Mb

Pubmed search

[1]

[2]

Helicase, lymphoid-specific, also known as HELLS, is a human gene.^[1]

This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: HELLS helicase, lymphoid-specific.

[edit] Further reading

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.". Cancer Lett. 197 (1-2): 63–8. PMID 12880961.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Geiman TM, Durum SK, Muegge K (1999). "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).". Genomics 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.
Lee DW, Zhang K, Ning ZQ, et al. (2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia.". Cancer Res. 60 (13): 3612–22. PMID 10910076.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sun LQ, Lee DW, Zhang Q, et al. (2004). "Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.". Genes Dev. 18 (9): 1035–46. doi:10.1101/gad.1176104. PMID 15105378.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Yano M, Ouchida M, Shigematsu H, et al. (2004). "Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer.". Int. J. Cancer 112 (1): 8–13. doi:10.1002/ijc.20407. PMID 15305370.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.