HDAC6

From Wikipedia, the free encyclopedia

Histone deacetylase 6

Identifiers

HDAC6; FLJ16239; HD6; JM21

External IDs

OMIM: 300272 MGI: 1333752 HomoloGene: 31353

Gene ontology
Molecular Function:	• actin binding • histone deacetylase activity • zinc ion binding • specific transcriptional repressor activity • hydrolase activity • histone deacetylase binding • tubulin deacetylase activity • metal ion binding
Cellular Component:	• histone deacetylase complex • nucleus • cytoplasm • microtubule
Biological Process:	• protein polyubiquitination • transcription • regulation of transcription, DNA-dependent • negative regulation of microtubule depolymerization • cell cycle • multicellular organismal development • chromatin modification • histone deacetylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006044 (mRNA)
NP_006035 (protein)

NM_010413 (mRNA)
NP_034543 (protein)

Location

Chr X: 48.55 - 48.57 Mb

n/a

Pubmed search

[1]

[2]

Histone deacetylase 6, also known as HDAC6, is a human gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Histone deacetylase

[edit] References

^ Entrez Gene: HDAC6 histone deacetylase 6.

[edit] Further reading

Pazin MJ, Kadonaga JT (1997). "What's up and down with histone deacetylation and transcription?". Cell 89 (3): 325–8. PMID 9150131.
Wolffe AP (1997). "Transcriptional control. Sinful repression.". Nature 387 (6628): 16–7. doi:10.1038/387016a0. PMID 9139815.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Grozinger CM, Hassig CA, Schreiber SL (1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4868–73. PMID 10220385.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression.". Genes Dev. 14 (14): 1810–23. PMID 10898795.
Mahlknecht U, Schnittger S, Landgraf F, et al. (2001). "Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization.". Cytogenet. Cell Genet. 93 (1-2): 135–6. PMID 11474198.
Kao HY, Lee CH, Komarov A, et al. (2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase.". J. Biol. Chem. 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242.
Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMID 11689694.
Tong JJ, Liu J, Bertos NR, Yang XJ (2002). "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain.". Nucleic Acids Res. 30 (5): 1114–23. PMID 11861901.
Gao L, Cueto MA, Asselbergs F, Atadja P (2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.". J. Biol. Chem. 277 (28): 25748–55. doi:10.1074/jbc.M111871200. PMID 11948178.
Hubbert C, Guardiola A, Shao R, et al. (2002). "HDAC6 is a microtubule-associated deacetylase.". Nature 417 (6887): 455–8. doi:10.1038/417455a. PMID 12024216.
Kirsh O, Seeler JS, Pichler A, et al. (2002). "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.". EMBO J. 21 (11): 2682–91. doi:10.1093/emboj/21.11.2682. PMID 12032081.
Hook SS, Orian A, Cowley SM, Eisenman RN (2002). "Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13425–30. doi:10.1073/pnas.172511699. PMID 12354939.
Westendorf JJ, Zaidi SK, Cascino JE, et al. (2002). "Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter.". Mol. Cell. Biol. 22 (22): 7982–92. PMID 12391164.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
North BJ, Marshall BL, Borra MT, et al. (2003). "The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.". Mol. Cell 11 (2): 437–44. PMID 12620231.
Voelter-Mahlknecht S, Mahlknecht U (2004). "Cloning and structural characterization of the human histone deacetylase 6 gene.". Int. J. Mol. Med. 12 (1): 87–93. PMID 12792815.
Brush MH, Guardiola A, Connor JH, et al. (2004). "Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.". J. Biol. Chem. 279 (9): 7685–91. doi:10.1074/jbc.M310997200. PMID 14670976.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.