HCST (gene)

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Hematopoietic cell signal transducer
Identifiers
Symbol(s) HCST; DAP10; DKFZP586C1522; KAP10; PIK3AP
External IDs OMIM: 604089 MGI: 1344360 HomoloGene: 8024
Orthologs
Human Mouse
Entrez 10870 23900
Ensembl ENSG00000126264 ENSMUSG00000064109
Refseq NM_001007469 (mRNA)
NP_001007470 (protein)		 NM_011827 (mRNA)
NP_035957 (protein)
Location Chr 19: 41.09 - 41.09 Mb Chr 7: 30.13 - 30.13 Mb
Pubmed search [1] [2]

Hematopoietic cell signal transducer, also known as HCST, is a human gene.[1]

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: HCST hematopoietic cell signal transducer.

[edit] Further reading

  • Karimi M, Cao TM, Baker JA, et al. (2006). "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells.". J. Immunol. 175 (12): 7819–28. PMID 16339517. 
  • André P, Castriconi R, Espéli M, et al. (2004). "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors.". Eur. J. Immunol. 34 (4): 961–71. doi:10.1002/eji.200324705. PMID 15048706. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.". Nat. Immunol. 4 (6): 557–64. doi:10.1038/ni929. PMID 12740575. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID 12426565. 
  • Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. 
  • Yim D, Jie HB, Sotiriadis J, et al. (2001). "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D.". Immunogenetics 53 (3): 243–9. PMID 11398969. 
  • Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123–33. PMID 11239445. 
  • Wu J, Cherwinski H, Spies T, et al. (2000). "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells.". J. Exp. Med. 192 (7): 1059–68. PMID 11015446. 
  • Chang C, Dietrich J, Harpur AG, et al. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.". J. Immunol. 163 (9): 4651–4. PMID 10528161. 
  • Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730–2. PMID 10426994. 
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