HCLS1

From Wikipedia, the free encyclopedia

Hematopoietic cell-specific Lyn substrate 1

Identifiers

HCLS1; HS1; CTTNL

External IDs

OMIM: 601306 MGI: 104568 HomoloGene: 38034

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • SH3 domain binding
Cellular Component:	• nucleus • DNA-directed RNA polymerase II, core complex • cytoplasm
Biological Process:	• regulation of transcription, DNA-dependent • intracellular signaling cascade • positive regulation of cell proliferation • response to hormone stimulus • erythrocyte differentiation • positive regulation of tyrosine phosphorylation of STAT protein

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005335 (mRNA)
NP_005326 (protein)

NM_008225 (mRNA)
NP_032251 (protein)

Location

Chr 3: 122.83 - 122.86 Mb

Chr 16: 36.86 - 36.88 Mb

Pubmed search

[1]

[2]

Hematopoietic cell-specific Lyn substrate 1, also known as HCLS1, is a human gene.^[1]

[edit] References

^ Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1.

[edit] Further reading

Kitamura D, Kaneko H, Miyagoe Y, et al. (1990). "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.". Nucleic Acids Res. 17 (22): 9367-79. PMID 2587259.
Yamanashi Y, Okada M, Semba T, et al. (1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3631-5. PMID 7682714.
Hata D, Nakamura T, Kawakami T, et al. (1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking.". Immunol. Lett. 40 (1): 65-71. PMID 7927516.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Egerton M, Moritz RL, Druker B, et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.". Biochem. Biophys. Res. Commun. 224 (3): 666-74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
Egashira M, Kitamura D, Watanabe T, Niikawa N (1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2-3): 175-6. PMID 8978766.
Suzuki Y, Demoliere C, Kitamura D, et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.". J. Immunol. 158 (6): 2736-44. PMID 9058808.
Yamanashi Y, Fukuda T, Nishizumi H, et al. (1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis.". J. Exp. Med. 185 (7): 1387-92. PMID 9104825.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Brunati AM, Donella-Deana A, James P, et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.". J. Biol. Chem. 274 (11): 7557-64. PMID 10066823.
Nagata Y, Kiefer F, Watanabe T, Todokoro K (1999). "Activation of hematopoietic progenitor kinase-1 by erythropoietin.". Blood 93 (10): 3347-54. PMID 10233887.
Takemoto Y, Furuta M, Sato M, et al. (2000). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.". Int. Immunol. 11 (12): 1957-64. PMID 10590261.
Ruzzene M, Brunati AM, Sarno S, et al. (2000). "Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2.". Eur. J. Biochem. 267 (10): 3065-72. PMID 10806407.
Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.". Biochem. Biophys. Res. Commun. 288 (4): 981-9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
Ruzzene M, Penzo D, Pinna LA (2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.". Biochem. J. 364 (Pt 1): 41-7. PMID 11988074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443-8. doi:10.1073/pnas.2436191100. PMID 12522270.
Uruno T, Zhang P, Liu J, et al. (2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.". Biochem. J. 371 (Pt 2): 485-93. doi:10.1042/BJ20021791. PMID 12534372.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186.