HBZ

From Wikipedia, the free encyclopedia

Hemoglobin, zeta

PDB rendering based on 1jeb.

Available structures: 1jeb

Identifiers

Symbol(s)

HBZ;

External IDs

OMIM: 142310 MGI: 96019 HomoloGene: 3896

Gene ontology
Molecular Function:	• oxygen transporter activity • iron ion binding • oxygen binding • heme binding • metal ion binding
Cellular Component:	• hemoglobin complex
Biological Process:	• transport • oxygen transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005332 (mRNA)
NP_005323 (protein)

NM_010405 (mRNA)
NP_034535 (protein)

Location

Chr 16: 0.14 - 0.14 Mb

Chr 11: 32.18 - 32.18 Mb

Pubmed search

[1]

[2]

Hemoglobin, zeta, also known as HBZ, is a human gene.^[1]

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult like. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.^[1]

[edit] References

^ ^a ^b Entrez Gene: HBZ hemoglobin, zeta.

[edit] Further reading

Higgs DR, Vickers MA, Wilkie AO, et al. (1989). "A review of the molecular genetics of the human alpha-globin gene cluster.". Blood 73 (5): 1081–104. PMID 2649166.
Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin.". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. PMID 7555018.
Proudfoot NJ, Brownlee GG (1976). "3' non-coding region sequences in eukaryotic messenger RNA.". Nature 263 (5574): 211–4. PMID 822353.
Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1).". Nucleic Acids Res. 20 (5): 1165. PMID 1549498.
Hess J, Perez-Stable C, Wu GJ, et al. (1985). "End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication.". J. Mol. Biol. 184 (1): 7–21. PMID 2411938.
Marotta CA, Forget BG, Weissman SM, et al. (1974). "Nucleotide sequences of human globin messenger RNA.". Proc. Natl. Acad. Sci. U.S.A. 71 (6): 2300–4. PMID 4135409.
Perez-Stable C, Ayres TM, Shen CK (1984). "Distinctive sequence organization and functional programming of an Alu repeat promoter.". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5291–5. PMID 6089189.
Clegg JB, Gagnon J (1982). "Structure of the zeta chain of human embryonic hemoglobin.". Proc. Natl. Acad. Sci. U.S.A. 78 (10): 6076–80. PMID 6171809.
Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G (1982). "[Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 362 (12): 1657–9. PMID 6172357.
Aschauer H, Sanguansermsri T, Braunitzer G (1982). "[Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 362 (8): 1159–62. PMID 6179844.
Proudfoot NJ, Gil A, Maniatis T (1983). "The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene.". Cell 31 (3 Pt 2): 553–63. PMID 6297773.
Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ (1983). "Molecular basis of length polymorphism in the human zeta-globin gene complex.". Proc. Natl. Acad. Sci. U.S.A. 80 (16): 5022–6. PMID 6308667.
Cohen-Solal MM, Authier B, deRiel JK, et al. (1983). "Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA.". DNA 1 (4): 355–63. PMID 6963223.
Orkin SH, Michelson A (1980). "Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia.". Nature 286 (5772): 538–40. PMID 7402334.
Flint J, Thomas K, Micklem G, et al. (1997). "The relationship between chromosome structure and function at a human telomeric region.". Nat. Genet. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID 9054936.
Luo HY, Liang XL, Frye C, et al. (1999). "Embryonic hemoglobins are expressed in definitive cells.". Blood 94 (1): 359–61. PMID 10381533.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.
Lau ET, Kwok YK, Chui DH, et al. (2001). "Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures.". Prenat. Diagn. 21 (7): 529–39. doi:10.1002/pd.81. PMID 11494285.