Hans Kosterlitz
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| Hans Kosterlitz | |
 Hans Kosterlitz
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| Born | 27 April 1903 |
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| Died | 26 October 1996 |
| Nationality | British |
| Fields | Biochemistry |
| Known for | endorphins |
Hans Walter Kosterlitz (27 April 1903 – 26 October 1996) was a British biologist, who graduated DrMed in Berlin. He settled in Scotland and took a DSc at the University of Aberdeen where he was, for many years, Reader in Physiology.
Kosterlitz is best known for his work on endorphins. He performed a famous experiment that he envisioned in a dream while sleeping. He stimulated a strip of guinea pig intestine electrically and was able to record the contractions with a polygraph. He then found that if you added opiates to the solution, the intestine would not contract. Opiates inhibit intestinal contraction. Those contractions were later found to resume in the presence of both opiates and an antagonist such as naloxone. Later, endogenous endorphins were discovered by applying tissue (mouse brain homegenate) to the apparatus. This caused the contractions to cease. The degree to which an opiate agonist causes contractions in the guinea pig ileum is highly correlated to its potency.
He was elected a Fellow of the Royal Society in 1978.
[edit] References
- Lees, G M (1998), “A tribute to the late Hans W. Kosterlitz: ploughing the lone furrow.”, Can. J. Physiol. Pharmacol. 76 (3): 244-51, 1998 Mar, PMID:9673787, <http://www.ncbi.nlm.nih.gov/pubmed/9673787>
- Hughes, J; Kosterlitz, H W & Smith, T W (1997), “The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 1977.”, Br. J. Pharmacol. 120 (4 Suppl): 428-36; discussion 426-7, 1997 Feb, PMID:9142421, <http://www.ncbi.nlm.nih.gov/pubmed/9142421>
- Henderson, G; Hughes, J & Kosterlitz, H W (1997), “A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens. 1972.”, Br. J. Pharmacol. 120 (4 Suppl): 396-8; discussion 393-5, 1997 Feb, PMID:9142417, <http://www.ncbi.nlm.nih.gov/pubmed/9142417>
- Hughes, J (1996), “Hans Kosterlitz (1903-96)”, Nature 384 (6608): 418, 1996 Dec 5, PMID:8945465, doi:10.1038/384418a0, <http://www.ncbi.nlm.nih.gov/pubmed/8945465>
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