Hans Adolf Krebs
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Hans Adolf Krebs  |
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 Hans Adolf Krebs
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| Born | August 25, 1900 Hildesheim, Germany |
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| Died | November 22 1981 (aged 81) Oxford, England |
| Residence | Germany till 1933,United Kingdom |
| Nationality | German, British |
| Fields | medical doctor and biochemist. |
| Institutions | Kaiser Wilhelm Institute for Biology University of Sheffield |
| Alma mater | University of Hamburg |
| Known for | discovery of the urea cycle and the citric acid cycle |
| Notable awards |  Nobel Prize in Physiology(1953) |
Sir Hans Adolf Krebs (August 25, 1900–November 22, 1981) was a German, later British medical doctor and biochemist. Krebs is best known for his identification of two important metabolic cycles: the urea cycle and the citric acid cycle. The latter, the key sequence of metabolic chemical reactions that produces energy in cells, is also known as the Krebs cycle and earned him a Nobel Prize in 1953.
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[edit] Life
He was born in Hildesheim, Germany, to Alma and Georg Krebs. His father, Georg, was an ear, nose, and throat surgeon. Hans went to school in Hildesheim and studied medicine at the University of Göttingen and at the University of Freiburg from 1918–1923. He earned his Ph.D. at the University of Hamburg in 1925, then studied chemistry in Berlin for one year, where he later became an assistant of Otto Warburg at the Kaiser Wilhelm Institute for Biology until 1930. He then returned to clinical medicine at the municipal hospital of Altona and then at the medical clinic of the University of Freiburg, where he conducted research and discovered the urea cycle.
Because he was Jewish, he was barred from practicing medicine in Germany and he emigrated to England in 1933. He was invited to Cambridge, where he worked in the biochemistry department under Sir Frederick Gowland Hopkins (1861–1947). Krebs became professor of biochemistry at the University of Sheffield in 1945. Krebs' area of interest was intermediary metabolism. He identified the urea cycle in 1932, and the citric acid cycle in 1937.
In 1953 he was awarded half of the Nobel Prize in Physiology for his "discovery of the citric acid cycle."
He was elected Honorary Fellow of Girton College, Cambridge University in 1979. Krebs died in Oxford, England in 1981. His son, John, Lord Krebs, is also a distinguished scientist.
[edit] Timeline
- 1900 Born in Germany
- 1918 Began medical school
- 1923 Graduated from medical school
- 1925 Graduated with Ph.D. from University of Hamburg
- 1932 Identification of Urea Cycle
- 1933 Emigration to the United Kingdom
- 1937 Identification of Citric Acid Cycle or "Krebs Cycle"
- 1945 Became a Professor at University of Sheffield
- 1953 Won the Nobel Prize in Medicine
- 1958 Knighted
- 1981 Died in the United Kingdom
[edit] References
- Weber, G (2001). Sir Hans A. Krebs Centenary Lecture: cancer and clinical targeting. Adv. Enzyme Regul. 41: 1-29. PMID 11417529.
- Stubbs, M; Gibbons G (Sep 2000). Hans Adolf Krebs (1900-1981)...his life and times. IUBMB Life 50 (3): 163-6. PMID 11142342.
- Raju, T N (May 1999). The Nobel chronicles. 1953: Hans Adolf Krebs (1900-81) and Fritz Albert Lipmann (1899-1986). Lancet 353 (9164): 1628. PMID 10334294.
- Kornberg, H; Williamson D H (1984). Hans Adolf Krebs: 25 August 1900-22 November 1981. Biographical memoirs of fellows of the Royal Society. Royal Society (Great Britain) 30: 351-85. PMID 11616005.
- Blaschko, H (1983). Obituary Hans Adolf Krebs (1900-1981). Rev. Physiol. Biochem. Pharmacol. 98: 1-9. PMID 6361963.
- Bolodia, G (Oct 1982). A tribute to professor Sir Hans A. Krebs, F.R.S. (1900-1981). Ethiop. Med. J. 20 (4): 213-9. PMID 6754370.
- Aspects of metabolic regulation. Papers contributed by some of his students and colleagues to mark the 80th birthday of H.A. Krebs, 25th August 1980 (Aug 1980). FEBS Lett. 117 Suppl: K1-134. PMID 6998726.
- Kenéz, J (Sep 1970). [H. A. Krebs and the biochemical lesion]. Orvosi hetilap 111 (38): 2247-9. PMID 4919448.
- Sulek, K (Dec 1968). [Nobel prize to Hans Adolf Krebs for discovery of the citric acid cycle and to Fritz Albert Lipmann in 1953 for discovery of coenzyme A and its importance in intermediary metabolism]. Wiad. Lek. 21 (23): 2187-9. PMID 4884999.
- Kornberg, H L (1968). H. A. Krebs: a pathway in metabolism. Biochem. Soc. Symp. 27: 3-9. PMID 4918525.
- BARNETT, C F (Nov 1963). USEFUL "USELESS INFORMATION"--A PARADOX (HANS ADOLF KREBS). The New physician 12: SUPPL A82-3. PMID 14059098.
- LEUTHARDT, F (Dec 1953). [H. A. Krebs.]. Experientia 9 (12): 474-5. PMID 13127871.
