HAMP

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"Hamp" redirects here. For the Japanese fighter plane, see A6M Zero.


Hepcidin antimicrobial peptide
PDB rendering based on 1m4f.
Available structures: 1m4f
Identifiers
Symbol(s) HAMP; HEPC; HFE2B; LEAP-1; LEAP1
External IDs OMIM: 606464 HomoloGene: 81623
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57817 n/a
Ensembl ENSG00000105697 n/a
Uniprot P81172 n/a
Refseq NM_021175 (mRNA)
NP_066998 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 19: 40.47 - 40.47 Mb n/a
Pubmed search [1] n/a

Hepcidin antimicrobial peptide, also known as HAMP, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: HAMP hepcidin antimicrobial peptide.

[edit] Further reading

  • Ganz T (2003). "Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.". Blood 102 (3): 783–8. doi:10.1182/blood-2003-03-0672. PMID 12663437. 
  • Roy CN, Andrews NC (2005). "Anemia of inflammation: the hepcidin link.". Curr. Opin. Hematol. 12 (2): 107–11. PMID 15725899. 
  • Fleming RE, Britton RS, Waheed A, et al. (2006). "Pathophysiology of hereditary hemochromatosis.". Semin. Liver Dis. 25 (4): 411–9. doi:10.1055/s-2005-923313. PMID 16315135. 
  • Krause A, Neitz S, Mägert HJ, et al. (2000). "LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity.". FEBS Lett. 480 (2-3): 147–50. PMID 11034317. 
  • Park CH, Valore EV, Waring AJ, Ganz T (2001). "Hepcidin, a urinary antimicrobial peptide synthesized in the liver.". J. Biol. Chem. 276 (11): 7806–10. doi:10.1074/jbc.M008922200. PMID 11113131. 
  • Pigeon C, Ilyin G, Courselaud B, et al. (2001). "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.". J. Biol. Chem. 276 (11): 7811–9. doi:10.1074/jbc.M008923200. PMID 11113132. 
  • Majore S, Binni F, Ricerca BM, et al. (2002). "Absence of hepcidin gene mutations in 10 Italian patients with primary iron overload.". Haematologica 87 (2): 221–2. PMID 11836175. 
  • Klüver E, Schulz A, Forssmann WG, Adermann K (2002). "Chemical synthesis of beta-defensins and LEAP-1/hepcidin.". J. Pept. Res. 59 (6): 241–8. PMID 12010514. 
  • Hunter HN, Fulton DB, Ganz T, Vogel HJ (2002). "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.". J. Biol. Chem. 277 (40): 37597–603. doi:10.1074/jbc.M205305200. PMID 12138110. 
  • Weinstein DA, Roy CN, Fleming MD, et al. (2003). "Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.". Blood 100 (10): 3776–81. doi:10.1182/blood-2002-04-1260. PMID 12393428. 
  • Nemeth E, Valore EV, Territo M, et al. (2003). "Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.". Blood 101 (7): 2461–3. doi:10.1182/blood-2002-10-3235. PMID 12433676. 
  • Roetto A, Papanikolaou G, Politou M, et al. (2003). "Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.". Nat. Genet. 33 (1): 21–2. doi:10.1038/ng1053. PMID 12469120. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gehrke SG, Kulaksiz H, Herrmann T, et al. (2003). "Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron.". Blood 102 (1): 371–6. doi:10.1182/blood-2002-11-3610. PMID 12637325. 
  • Merryweather-Clarke AT, Cadet E, Bomford A, et al. (2004). "Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis.". Hum. Mol. Genet. 12 (17): 2241–7. doi:10.1093/hmg/ddg225. PMID 12915468. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Roetto A, Daraio F, Porporato P, et al. (2004). "Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R).". Blood 103 (6): 2407–9. doi:10.1182/blood-2003-10-3390. PMID 14630809. 
  • Jacolot S, Le Gac G, Scotet V, et al. (2004). "HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype.". Blood 103 (7): 2835–40. doi:10.1182/blood-2003-10-3366. PMID 14670915. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
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Metabolism: Iron metabolism (including iron-binding proteins)
Absorption in duodenum
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