Haloacetate dehalogenase

From Wikipedia, the free encyclopedia

In enzymology, a haloacetate dehalogenase (EC 3.8.1.3) is an enzyme that catalyzes the chemical reaction

haloacetate + H₂O glycolate + halide

Thus, the two substrates of this enzyme are haloacetate and H₂O, whereas its two products are glycolate and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is haloacetate halidohydrolase. This enzyme is also called monohaloacetate dehalogenase. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,2-dichloroethane degradation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1Y37.

[edit] References

• IUBMB entry for 3.8.1.3
• BRENDA references for 3.8.1.3 (Recommended.)
• PubMed references for 3.8.1.3
• PubMed Central references for 3.8.1.3
• Google Scholar references for 3.8.1.3
• GOLDMAN P (1965). "THE ENZYMATIC CLEAVAGE OF THE CARBON-FLUORINE BOND IN FLUOROACETATE". J. Biol. Chem. 240: 3434–8. PMID 14321384. 
• Goldman P, Milne GW (1966). "Carbon-fluorine bond cleavage. II. Studies on the mechanism of the defluorination of fluoroacetate". J. Biol. Chem. 241: 5557–9. PMID 5928195. 

[edit] External links

The CAS registry number for this enzyme class is 37289-40-0.

• IUBMB entry for 3.8.1.3

• KEGG entry for 3.8.1.3

• BRENDA entry for 3.8.1.3

• NiceZyme view of 3.8.1.3

• EC2PDB: PDB structures for 3.8.1.3

• PRIAM entry for 3.8.1.3

• PUMA2 entry for 3.8.1.3

• IntEnz: Integrated Enzyme entry for 3.8.1.3

• MetaCyc entry for 3.8.1.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018785: haloacetate dehalogenase

• AMIGO entry for GO code 0018785: haloacetate dehalogenase