Halazepam
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Halazepam
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Systematic (IUPAC) name | |
9-chloro-6-phenyl-2-(2,2,2-trifluoroethyl)-2,5-diazabicyclo [5.4.0]undeca-5,8,10,12-tetraen-3-one |
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Identifiers | |
CAS number | |
ATC code | N05 |
PubChem | |
DrugBank | |
Chemical data | |
Formula | C17H12ClF3N2O |
Mol. mass | 352.7 |
Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | Hepatic |
Half life | ? |
Excretion | Renal |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status |
Schedule IV (US) |
Routes | Oral |
Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam.[1] While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.[2]
[edit] References
- ^ Greenblatt, D. J.; A. Locniskar and R. I. Shader (June 12, 1982). "Halazepam, another precursor of desmethyldiazepam". Lancet 1 (8285): 1358–9. PMID 6123659.
- ^ Fann, W. E.; W. M. Pitts and J. C. Wheless (Mar-Apr 1982). "Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine". Pharmacotherapy 2 (2): 72–9. PMID 6152591.
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