HAGH

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Hydroxyacylglutathione hydrolase
PDB rendering based on 1qh3.
Available structures: 1qh3, 1qh5
Identifiers
Symbol(s) HAGH; GLO2; GLX2; GLXII; HAGH1
External IDs OMIM: 138760 MGI: 95745 HomoloGene: 3890
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3029 14651
Ensembl ENSG00000063854 ENSMUSG00000024158
Uniprot Q16775 Q3TMR4
Refseq NM_001040427 (mRNA)
NP_001035517 (protein)		 NM_024284 (mRNA)
NP_077246 (protein)
Location Chr 16: 1.8 - 1.82 Mb Chr 17: 24.58 - 24.59 Mb
Pubmed search [1] [2]

Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.[1]

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.[1]

[edit] References

  1. ^ a b Entrez Gene: HAGH hydroxyacylglutathione hydrolase.

[edit] Further reading

  • Kar NC, Pearson CM (1976). "Glyoxalase enzyme system in human muscular dystrophy.". Clin. Chim. Acta 65 (1): 153-5. PMID 1192606. 
  • Hamilton DS, Creighton DJ (1993). "Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy.". J. Biol. Chem. 267 (35): 24933-6. PMID 1459997. 
  • Mulley JC, Barton N, Callen DF (1990). "Localisation of human PGP and HAGH genes to 16p13.3.". Cytogenet. Cell Genet. 53 (2-3): 175-6. PMID 2164460. 
  • Mulley JC, Callen DF (1987). "New regional localisations for HAGH and PGP on human chromosome 16.". Hum. Genet. 74 (4): 423-4. PMID 3025077. 
  • Talesa V, Uotila L, Koivusalo M, et al. (1988). "Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms.". Biochim. Biophys. Acta 955 (1): 103-10. PMID 3382669. 
  • Thornalley PJ, Bellavite P (1987). "Modification of the glyoxalase system during the functional activation of human neutrophils.". Biochim. Biophys. Acta 931 (2): 120-9. PMID 3663711. 
  • Valentine WN, Paglia DE, Neerhout RC, Konrad PN (1971). "Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis.". Blood 36 (6): 797-808. PMID 5485124. 
  • Leoncini G, Maresca M, Balestrero F, et al. (1984). "Platelet glyoxalases in thrombocytosis.". Scandinavian journal of haematology 33 (1): 91-4. PMID 6463589. 
  • Honey NK, Shows TB (1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16.". Hum. Genet. 58 (4): 358-61. PMID 7327557. 
  • Board PG (1980). "Genetic polymorphism of human erythrocyte glyoxalase II.". Am. J. Hum. Genet. 32 (5): 690-4. PMID 7424909. 
  • Di Ilio C, Angelucci S, Pennelli A, et al. (1995). "Glyoxalase activities in tumor and non-tumor human urogenital tissues.". Cancer Lett. 96 (2): 189-93. PMID 7585456. 
  • Ridderström M, Saccucci F, Hellman U, et al. (1996). "Molecular cloning, heterologous expression, and characterization of human glyoxalase II.". J. Biol. Chem. 271 (1): 319-23. PMID 8550579. 
  • Cameron AD, Ridderström M, Olin B, Mannervik B (1999). "Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue.". Structure 7 (9): 1067-78. PMID 10508780. 
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339-52. PMID 11157797. 
  • Rulli A, Carli L, Romani R, et al. (2001). "Expression of glyoxalase I and II in normal and breast cancer tissues.". Breast Cancer Res. Treat. 66 (1): 67-72. PMID 11368412. 
  • Scirè A, Saccucci F, Bertoli E, et al. (2002). "Effect of acidic phospholipids on the structural properties of recombinant cytosolic human glyoxalase II.". Proteins 48 (1): 126-33. doi:10.1002/prot.10149. PMID 12012344. 
  • Mearini E, Romani R, Mearini L, et al. (2002). "Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas.". Eur. J. Cancer 38 (14): 1946-50. PMID 12204678. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cordell PA, Futers TS, Grant PJ, Pease RJ (2004). "The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II.". J. Biol. Chem. 279 (27): 28653-61. doi:10.1074/jbc.M403470200. PMID 15117945. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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