Haemorrhagic disease of the newborn

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Haemorrhagic disease of the newborn
Classification and external resources
Vitamin K1
ICD-10 P53.
ICD-9 776.0
DiseasesDB 29544
eMedicine ped/966 
MeSH D006475

Haemorrhagic disease of the newborn is a coagulation disturbance in newborns due to vitamin K deficiency. As a consequence of vitamin K deficiency there is an impaired production of coagulation factors II, VII, IX, X, C and S by the liver.

[edit] Causes

Newborns are relatively vitamin K deficient for a variety of reasons. They have low vitamin K stores at birth, vitamin K passes the placenta poorly, the levels of vitamin K in breast milk are low and the gut flora has not yet been developed (vitamin K is normally produced by bacteria in the intestines).

[edit] Presentation

The disease causes an increased risk of bleeding. The most common sites of bleeding are the umbilicus, mucous membranes, gastrointestinal tract, circumcision and venipunctures.

[edit] Treatment

Treatment consists of vitamin K supplementation. This is often given prophylactically newborns shortly after birth.