H1FX

From Wikipedia, the free encyclopedia

H1 histone family, member X

Identifiers

H1FX; H1X; MGC15959; MGC8350

External IDs

OMIM: 602785 MGI: 2685307 HomoloGene: 4397

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleosome • nucleus • chromosome
Biological Process:	• nucleosome assembly • chromosome organization and biogenesis (sensu Eukaryota)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006026 (mRNA)
NP_006017 (protein)

XM_981507 (mRNA)
XP_986601 (protein)

Location

Chr 3: 130.52 - 130.52 Mb

Chr 6: 87.95 - 87.95 Mb

Pubmed search

[1]

[2]

H1 histone family, member X, also known as H1FX, is a human gene.^[1]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.^[1]

[edit] References

^ ^a ^b Entrez Gene: H1FX H1 histone family, member X.

[edit] Further reading

Ohsumi K, Katagiri C (1991). "Occurrence of H1 subtypes specific to pronuclei and cleavage-stage cell nuclei of anuran amphibians.". Dev. Biol. 147 (1): 110-20. PMID 1879604.
Yamamoto T, Horikoshi M (1996). "Cloning of the cDNA encoding a novel subtype of histone H1.". Gene 173 (2): 281-5. PMID 8964515.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus.". Hum. Genet. 101 (3): 284-94. PMID 9439656.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sulimova GE, Kutsenko AS, Rakhmanaliev ER, et al. (2003). "Human chromosome 3: integration of 60 NotI clones into a physical and gene map.". Cytogenet. Genome Res. 98 (2-3): 177-83. doi:10.1159/000069814. PMID 12698000.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.". J. Proteome Res. 3 (6): 1219-27. doi:10.1021/pr0498887. PMID 15595731.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.
Happel N, Schulze E, Doenecke D (2005). "Characterisation of human histone H1x.". Biol. Chem. 386 (6): 541-51. doi:10.1515/BC.2005.064. PMID 16006241.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Takata H, Matsunaga S, Morimoto A, et al. (2007). "H1.X with different properties from other linker histones is required for mitotic progression.". FEBS Lett. 581 (20): 3783-8. doi:10.1016/j.febslet.2007.06.076. PMID 17632103.