GZMM

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Granzyme M (lymphocyte met-ase 1)
Identifiers
Symbol(s) GZMM; LMET1; MET1
External IDs OMIM: 600311 MGI: 99549 HomoloGene: 21099
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3004 16904
Ensembl ENSG00000197540 ENSMUSG00000054206
Uniprot P51124 n/a
Refseq NM_005317 (mRNA)
NP_005308 (protein)		 NM_008504 (mRNA)
NP_032530 (protein)
Location Chr 19: 0.5 - 0.5 Mb Chr 10: 79.09 - 79.1 Mb
Pubmed search [1] [2]

Granzyme M (lymphocyte met-ase 1), also known as GZMM, is a human gene.[1]

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.[1]

[edit] References

  1. ^ a b Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1).

[edit] Further reading

  • Smyth MJ, O'Connor MD, Trapani JA (1996). "Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.". J. Leukoc. Biol. 60 (5): 555-62. PMID 8929545. 
  • Pilat D, Fink T, Obermaier-Skrobanek B, et al. (1995). "The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3.". Genomics 24 (3): 445-50. doi:10.1006/geno.1994.1651. PMID 7713495. 
  • Baker E, Sutherland GR, Smyth MJ (1994). "The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3.". Immunogenetics 39 (4): 294-5. PMID 8119738. 
  • Smyth MJ, Sayers TJ, Wiltrout T, et al. (1994). "Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.". J. Immunol. 151 (11): 6195-205. PMID 8245461. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Krenacs L, Smyth MJ, Bagdi E, et al. (2003). "The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity.". Blood 101 (9): 3590-3. doi:10.1182/blood-2002-09-2908. PMID 12506019. 
  • Kelly JM, Waterhouse NJ, Cretney E, et al. (2004). "Granzyme M mediates a novel form of perforin-dependent cell death.". J. Biol. Chem. 279 (21): 22236-42. doi:10.1074/jbc.M401670200. PMID 15028722. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.". J. Biol. Chem. 279 (52): 54275-82. doi:10.1074/jbc.M411482200. PMID 15494398. 
  • Lu H, Hou Q, Zhao T, et al. (2006). "Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation.". J. Immunol. 177 (2): 1171-8. PMID 16818775. 
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