GZMB

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Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
PDB rendering based on 1fq3.
Available structures: 1fq3, 1iau
Identifiers
Symbol(s)	GZMB; HLP; CTLA1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTSGL1; SECT
External IDs	OMIM: 123910 MGI: 109267 HomoloGene: 20876
Gene ontology Molecular Function: • serine-type endopeptidase activity • granzyme B activity • peptidase activity Cellular Component: • immunological synapse • nucleus • cytoplasm Biological Process: • proteolysis • apoptosis • cleavage of lamin • cytolysis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3002	14939
Ensembl	ENSG00000100453	ENSMUSG00000015437
Uniprot	P10144	Q3TIP3
Refseq	NM_004131 (mRNA) NP_004122 (protein)	NM_013542 (mRNA) NP_038570 (protein)
Location	Chr 14: 24.17 - 24.17 Mb	Chr 14: 55.21 - 55.22 Mb
Pubmed search	[1]	[2]

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), also known as GZMB, is a human gene.

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.^[1]

[edit] See also

• Granzyme

[edit] References

[edit] Further reading

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