GYPB
From Wikipedia, the free encyclopedia
|
Glycophorin B (MNS blood group)
|
||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | GYPB; SS; MNS; GPB; GYPA; CD235b; GPB.NY; GYPHe.NY | |||||||||||||
| External IDs | OMIM: 111740 | |||||||||||||
|
||||||||||||||
| RNA expression pattern | ||||||||||||||
|
|
||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 2994 | n/a | ||||||||||||
| Ensembl | ENSG00000153143 | n/a | ||||||||||||
| Uniprot | P06028 | n/a | ||||||||||||
| Refseq | NM_002100 (mRNA) NP_002091 (protein) |
n/a (mRNA) n/a (protein) |
||||||||||||
| Location | Chr 4: 145.14 - 145.16 Mb | n/a | ||||||||||||
| Pubmed search | [1] | n/a | ||||||||||||
Glycophorin B (MNS blood group), also known as GYPB, is a human gene.[1] GYPB has also recently been designated CD235b (cluster of differentiation 235b).
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.[1]
[edit] References
[edit] Further reading
- Blumenfeld OO, Huang CH (1996). "Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification.". Hum. Mutat. 6 (3): 199–209. doi:. PMID 8535438.
- Blumenfeld OO, Huang CH (1997). "Molecular genetics of glycophorin MNS variants.". Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 4 (4): 357–65. PMID 9269716.
- Huang CH, Spruell P, Moulds JJ, Blumenfeld OO (1992). "Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype.". Blood 80 (1): 257–63. PMID 1611092.
- Rearden A, Phan H, Dubnicoff T, et al. (1990). "Identification of the crossing-over point of a hybrid gene encoding human glycophorin variant Sta. Similarity to the crossing-over point in haptoglobin-related genes.". J. Biol. Chem. 265 (16): 9259–63. PMID 1971625.
- Huang CH, Blumenfeld OO (1991). "Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins.". Blood 77 (8): 1813–20. PMID 2015404.
- Huang CH, Blumenfeld OO (1991). "Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification.". J. Biol. Chem. 266 (11): 7248–55. PMID 2016325.
- Kudo S, Fukuda M (1990). "Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction.". J. Biol. Chem. 265 (2): 1102–10. PMID 2295603.
- Kudo S, Fukuda M (1989). "Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences.". Proc. Natl. Acad. Sci. U.S.A. 86 (12): 4619–23. PMID 2734312.
- Tate CG, Tanner MJ (1988). "Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta.". Biochem. J. 254 (3): 743–50. PMID 3196288.
- Siebert PD, Fukuda M (1987). "Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A.". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6735–9. PMID 3477806.
- Blanchard D, Dahr W, Hummel M, et al. (1987). "Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis.". J. Biol. Chem. 262 (12): 5808–11. PMID 3571235.
- Dahr W, Beyreuther K, Moulds J, Unger P (1987). "Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety.". Eur. J. Biochem. 166 (1): 31–6. PMID 3595615.
- Onda M, Fukuda M (1995). "Detailed physical mapping of the genes encoding glycophorins A, B and E, as revealed by P1 plasmids containing human genomic DNA.". Gene 159 (2): 225–30. PMID 7622054.
- Kudo S, Onda M, Fukuda M (1995). "Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals.". J. Biochem. 116 (1): 183–92. PMID 7798177.
- Rahuel C, Elouet JF, Cartron JP (1995). "Post-transcriptional regulation of the cell surface expression of glycophorins A, B, and E.". J. Biol. Chem. 269 (52): 32752–8. PMID 7806496.
- Huang CH, Reid ME, Blumenfeld OO (1994). "Remodeling of the transmembrane segment in human glycophorin by aberrant RNA splicing.". J. Biol. Chem. 269 (14): 10804–12. PMID 8144668.
- Huang CH, Lomas C, Daniels G, Blumenfeld OO (1994). "Glycophorin He(Sta) of the human red blood cell membrane is encoded by a complex hybrid gene resulting from two recombinational events.". Blood 83 (11): 3369–76. PMID 8193374.
- Huang CH, Reid ME, Blumenfeld OO (1993). "Exon skipping caused by DNA recombination that introduces a defective donor splice site into the human glycophorin A gene.". J. Biol. Chem. 268 (7): 4945–52. PMID 8444872.
- Cherif-Zahar B, Raynal V, Gane P, et al. (1996). "Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency.". Nat. Genet. 12 (2): 168–73. doi:. PMID 8563755.
[edit] External links
 |
This membrane protein-related article is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
