GYPA

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Glycophorin A (MNS blood group)
PDB rendering based on 1afo.
Available structures: 1afo
Identifiers
Symbol(s) GYPA; MN; MNS; CD235a; GPA; GPErik; GPSAT; GpMiIII; HGpMiIII; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C)
External IDs OMIM: 111300 HomoloGene: 48076
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2993 n/a
Ensembl ENSG00000170180 n/a
Uniprot P02724 n/a
Refseq NM_002099 (mRNA)
NP_002090 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 4: 145.25 - 145.28 Mb n/a
Pubmed search [1] n/a

Glycophorin A (MNS blood group), also known as GYPA, is a human gene.[1] GYPA has also recently been designated CD235a (cluster of differentiation 235a).

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPA gene consists of 7 exons and has 97% sequence homology with GYPB from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.[1]

[edit] References

  1. ^ a b Entrez Gene: GYPA glycophorin A (MNS blood group).

[edit] Further reading

  • Blumenfeld OO, Huang CH (1996). "Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification.". Hum. Mutat. 6 (3): 199–209. doi:10.1002/humu.1380060302. PMID 8535438. 
  • Blumenfeld OO, Huang CH (1997). "Molecular genetics of glycophorin MNS variants.". Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 4 (4): 357–65. PMID 9269716. 
  • Johnson ST, McFarland JG, Kelly KJ, et al. (2002). "Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination.". Transfusion 42 (5): 567–71. PMID 12084164. 
  • Tomita M, Marchesi VT (1976). "Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin.". Proc. Natl. Acad. Sci. U.S.A. 72 (8): 2964–8. PMID 1059087. 
  • Lemmon MA, Flanagan JM, Hunt JF, et al. (1992). "Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.". J. Biol. Chem. 267 (11): 7683–9. PMID 1560003. 
  • Huang CH, Spruell P, Moulds JJ, Blumenfeld OO (1992). "Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype.". Blood 80 (1): 257–63. PMID 1611092. 
  • Huang CH, Kikuchi M, McCreary J, Blumenfeld OO (1992). "Gene conversion confined to a direct repeat of the acceptor splice site generates allelic diversity at human glycophorin (GYP) locus.". J. Biol. Chem. 267 (5): 3336–42. PMID 1737789. 
  • Barton P, Collins A, Hoogenraad N (1991). "A variant of glycophorin A resulting from the deletion of exon 4.". Biochim. Biophys. Acta 1090 (2): 265–6. PMID 1932122. 
  • Huang CH, Blumenfeld OO (1991). "Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins.". Blood 77 (8): 1813–20. PMID 2015404. 
  • Huang CH, Blumenfeld OO (1991). "Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification.". J. Biol. Chem. 266 (11): 7248–55. PMID 2016325. 
  • Hamid J, Burness AT (1990). "The mechanism of production of multiple mRNAs for human glycophorin A.". Nucleic Acids Res. 18 (19): 5829–36. PMID 2216775. 
  • Dill K, Hu SH, Berman E, et al. (1990). "One- and two-dimensional NMR studies of the N-terminal portion of glycophorin A at 11.7 Tesla.". J. Protein Chem. 9 (2): 129–36. PMID 2386609. 
  • Kudo S, Fukuda M (1989). "Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences.". Proc. Natl. Acad. Sci. U.S.A. 86 (12): 4619–23. PMID 2734312. 
  • Matsui Y, Natori S, Obinata M (1989). "Isolation of the cDNA clone for mouse glycophorin, erythroid-specific membrane protein.". Gene 77 (2): 325–32. PMID 2753361. 
  • Vignal A, Rahuel C, el Maliki B, et al. (1989). "Molecular analysis of glycophorin A and B gene structure and expression in homozygous Miltenberger class V (Mi. V) human erythrocytes.". Eur. J. Biochem. 184 (2): 337–44. PMID 2792104. 
  • Tate CG, Tanner MJ (1988). "Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta.". Biochem. J. 254 (3): 743–50. PMID 3196288. 
  • Huang CH, Puglia KV, Bigbee WL, et al. (1989). "A family study of multiple mutations of alpha and delta glycophorins (glycophorins A and B).". Hum. Genet. 81 (1): 26–30. PMID 3198123. 
  • Rahuel C, London J, d'Auriol L, et al. (1988). "Characterization of cDNA clones for human glycophorin A. Use for gene localization and for analysis of normal of glycophorin-A-deficient (Finnish type) genomic DNA.". Eur. J. Biochem. 172 (1): 147–53. PMID 3345758. 
  • Siebert PD, Fukuda M (1986). "Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure.". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1665–9. PMID 3456608. 
  • Siebert PD, Fukuda M (1987). "Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A.". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6735–9. PMID 3477806. 

[edit] External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350